Predictive factors for the development of brain metastases in patients with malignant melanoma: a study by the Anatolian society of medical oncology

Autor: Umut Demirci, Ahmet Alacacioglu, Faysal Dane, Mehmet Ali Kaplan, Gamze Goksel, Ahmet Siyar Ekinci, Ugur Coskun, Muharrem Kocar, Bulent Cetin, Efnan Algin, Mahmut Gumus, Ozan Yazici, Suleyman Buyukberber, Berna Oksuzoglu, Özlem Balvan Erceleb, Ayhan Yildiz, Ozge Gumusay, Mukremin Uysal, Veli Berk, Tulay Akman, Burcu Yapar Taskoylu, Ilhan Oztop
Rok vydání: 2013
Předmět:
Male
Oncology
Cancer Research
retrospective study
very elderly
primary tumor
middle aged
brain metastasis
cancer survival
Melanoma
Aged
80 and over
Hematology
predictive value
Brain Neoplasms
adult
Incidence (epidemiology)
digestive
oral
and skin physiology
article
General Medicine
Middle Aged
aged
female
priority journal
Predictive value of tests
young adult
Female
Predictive factors
Median survival
survival rate
Adult
Poor prognosis
medicine.medical_specialty
education
tumor localization
male
Predictive Value of Tests
Internal medicine
melanoma
medicine
Humans
controlled study
In patient
human
survival time
Aged
Neoplasm Staging
Retrospective Studies
ulcer
business.industry
cancer staging
Brain metastases
Retrospective cohort study
medicine.disease
major clinical study
clinical feature
stomatognathic diseases
Logistic Models
cancer size
business
Zdroj: Journal of Cancer Research and Clinical Oncology. 140:151-157
ISSN: 1432-1335
0171-5216
DOI: 10.1007/s00432-013-1553-7
Popis: Background: The development of brain metastases (BMs) was associated with poor prognosis in melanoma patients. Patients with BMs have a median survival of 4 mm) (p = 0.008), ulceration (p = 0.007), and pathologically N2 and N3 diseases (p = 0.001) were found to be significantly associated with the development of BMs. In univariate analysis, tumor thickness and performance status had a significant influence on post-BMs survival. In multivariate analysis, these clinicopathologic factors were not remained as significant predictive factors. Conclusions: Our results revealed the importance of primary tumor characteristics associated with the development of BMs. Ulceration, primary tumor thickness, anatomic site, and pathologic ≥N2 disease were found to be significant predictors of BMs development. © 2013 Springer-Verlag Berlin Heidelberg.
Databáze: OpenAIRE
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