A treatise on benzimidazole based Schiff base metal(II) complexes accentuating their biological efficacy: Spectroscopic evaluation of DNA interactions, DNA cleavage and antimicrobial screening
| Autor: | Ganesan Kumaravel, Natarajan Raman |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Circular dichroism
Benzimidazole Spectrophotometry Infrared Stereochemistry Proton Magnetic Resonance Spectroscopy Intercalation (chemistry) Molar conductivity Bioengineering Microbial Sensitivity Tests 010402 general chemistry Ligands 01 natural sciences Mass Spectrometry law.invention Biomaterials chemistry.chemical_compound Magnetics Transition metal law Coordination Complexes Electrochemistry Imidazole DNA Cleavage Electron paramagnetic resonance Schiff Bases Electrophoresis Agar Gel Schiff base Bacteria 010405 organic chemistry Viscosity Circular Dichroism Electric Conductivity Electron Spin Resonance Spectroscopy DNA 0104 chemical sciences Anti-Bacterial Agents Crystallography Spectrometry Fluorescence chemistry Mechanics of Materials Benzimidazoles |
| Zdroj: | Materials scienceengineering. C, Materials for biological applications. 70(Pt 1) |
| ISSN: | 1873-0191 |
| Popis: | Two novel imidazole derived Schiff bases, (Z)-1-(1H-benzo[ d ]imidazol-2-yl)- N -benzylidenemethanamine (L 1 ) and 1-(1H-benzo[ d ]imidazol-2-yl)- N -(4-nitrobenzylidene) methanamine, and a series of their transition metal complexes of the types [M(L 1 ) 2 ]Cl 2 and [M(L 2 ) 2 ]Cl 2 where, M = Cu(II), Ni(II), Co(II) and Zn(II) have been designed and synthesized. These compounds were characterized by various spectral and physicochemical data. UV–Vis, magnetic susceptibility and molar conductivity data indicate that all the complexes adopt square planar geometry. The EPR spectral data of the Cu(II) complexes have provided supportive evidence to the conclusion derived on the basis of electronic absorption and magnetic moment values. Moreover, the interaction of complexes with DNA via intercalation has been explored by absorption, fluorescence spectroscopy, cyclic voltammetry, viscosity and circular dichroism. Agarose gel electrophoresis technique reveals that the complexes are good metallonucleases. All the compounds have relatively high antibacterial and antifungal potencies. Among the metal complexes, Cu(II) complexes exhibit higher efficacy against all the pathogens. |
| Databáze: | OpenAIRE |
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