Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
| Autor: | Marcus Ståhlman, Patrick Schrauwen, Carlijn M. E. Remie, Pandichelvam Veeraiah, Martijn C. G. J. Brouwers, Bas Havekes, Yvonne M. H. Bruls, Vera B. Schrauwen-Hinderling, Esther Phielix, Renée de Mutsert, Marja-Riitta Taskinen, Kay H. M. Roumans, Lucas Lindeboom, Jan Borén, Bart Staels, Marjan Alssema, Harry P. F. Peters |
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| Přispěvatelé: | Maastricht University [Maastricht], Maastricht University Medical Centre (MUMC), University of Gothenburg (GU), Sahlgrenska University Hospital [Gothenburg], Unilever Food Innovation Center [Wageningue, Pays-Bas], Leiden University Medical Center (LUMC), Universiteit Leiden, Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (RNMCD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, This research was in part financed by the Ministry of Economic Affairs and Climate Policy by means of the PPP Allowance made available by the Top Sector Life Sciences & Health to stimulate public–private partnerships and by Unilever R&D Wageningen. We acknowledge the support from the Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation (CVON2014-02 ENERGISE). L.L. is a recipient of a veni grant from ZonMW (016.veni.188.036) and a junior fellowship (2017.81.004) from the Diabetes Fonds (Dutch Diabetes Research Foundation). B.S. is a recipient of an Advanced ERC Grant (694717). V.B.S.-H. is a recipient of an ERC starting grant (grant no. 759161 ‘MRS in diabetes’)., European Project: 694717,H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) ,ImmunoBile(2016), Nutrition and Movement Sciences, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, Beeldvorming, Interne Geneeskunde, MUMC+: MA Endocrinologie (9), RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: DA BV Research (9), MUMC+: DA BV Klinisch Fysicus (9), University of Helsinki, HUS Heart and Lung Center, Clinicum, CAMM - Research Program for Clinical and Molecular Metabolism, Research Programs Unit, Bodescot, Myriam, Bile acid, immune-metabolism, lipid and glucose homeostasis - ImmunoBile - - H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) 2016-09-01 - 2021-08-31 - 694717 - VALID |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Type 2/metabolism General Physics and Astronomy Type 2 diabetes Lipogenesis/physiology 0302 clinical medicine Non-alcoholic Fatty Liver Disease Triglycerides/metabolism BRAIN lcsh:Science RISK chemistry.chemical_classification SPECTROSCOPY Multidisciplinary Fatty liver Fatty Acids food and beverages Liver/diagnostic imaging Middle Aged Lipids 3. Good health Fatty Acids/metabolism Adipose Tissue Liver CARDIOVASCULAR-DISEASE Lipogenesis Saturated fatty acid Female Polyunsaturated fatty acid Adult medicine.medical_specialty Science 030209 endocrinology & metabolism General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Insulin resistance Non-alcoholic Fatty Liver Disease/metabolism LIVER-DISEASE Diabetes mellitus Internal medicine Diabetes Mellitus medicine STEATOSIS Humans Triglycerides Aged [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology General Chemistry medicine.disease Diabetes Mellitus Type 2/metabolism [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology MICE 030104 developmental biology Endocrinology Cross-Sectional Studies chemistry Diabetes Mellitus Type 2 3121 General medicine internal medicine and other clinical medicine lcsh:Q Steatosis Insulin Resistance Insulin Resistance/physiology |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020) Nature Communications Nature Communications, 2020, 11 (1), pp.1891. ⟨10.1038/s41467-020-15684-0⟩ Nature Communications, 11(1):1891. Nature Publishing Group Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.1891. ⟨10.1038/s41467-020-15684-0⟩ Nature Communications, 11(1). NATURE PUBLISHING GROUP |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-15684-0⟩ |
| Popis: | Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Hepatic saturated fatty acids (SFA) may be a marker of DNL and are suggested to be most detrimental in contributing to insulin resistance. Here, we show in a cross-sectional study design (ClinicalTrials.gov ID: NCT03211299) that we are able to distinguish the fractions of hepatic SFA, mono- and polyunsaturated fatty acids in healthy and metabolically compromised volunteers using proton magnetic resonance spectroscopy (1H-MRS). DNL is positively associated with SFA fraction and is elevated in patients with non-alcoholic fatty liver and type 2 diabetes. Intriguingly, SFA fraction shows a strong, negative correlation with hepatic insulin sensitivity. Our results show that the hepatic lipid composition, as determined by our 1H-MRS methodology, is a measure of DNL and suggest that specifically the SFA fraction may hamper hepatic insulin sensitivity. Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Here, the authors use 1H-MRS methodology to show hepatic SFA fraction is a measure of DNL and specifically may hamper hepatic insulin sensitivity. |
| Databáze: | OpenAIRE |
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