Comparison of therapeutic effects between topical 8-oxo-2′-deoxyguanosine and corticosteroid in ocular alkali burn model

Autor:	Myung Hee Chung, Chul Park, Sang Taek Im, Mee Kum Kim, Dong Hyun Kim, Jin Young Yoon, Seunghoon Kim
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	0301 basic medicine medicine.drug_class Science Drug Evaluation Preclinical Administration Ophthalmic Pharmacology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cornea Burns Chemical medicine Animals Sodium Hydroxide heterocyclic compounds Eye diseases Glucocorticoids Reactive nitrogen species Fluorometholone Mice Inbred BALB C Multidisciplinary NADPH oxidase biology Interleukin Eye Burns 030104 developmental biology medicine.anatomical_structure chemistry Preclinical research 8-Hydroxy-2'-Deoxyguanosine Neutrophil elastase 030221 ophthalmology & optometry biology.protein Corticosteroid Medicine Female sense organs Nicotinamide adenine dinucleotide phosphate medicine.drug Corneal Injuries
Zdroj:	Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) Scientific Reports
ISSN:	2045-2322
Popis:	We compared the therapeutic effects of topical 8-oxo-2′-deoxyguanosine (8-oxo-dG) and corticosteroid in a murine ocular alkali burn model. (n = 128) The corneal alkali burn model was established by applying 0.1 N sodium hydroxide (NaOH), followed by treatment with 8-oxo-dG, 0.1% fluorometholone (FML), 1% prednisolone acetate (PDE), or phosphate-buffered saline (PBS) twice daily. One week later, the clinical and histological status of the cornea were assessed. Transcript levels of inflammatory cytokines and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase as well as the levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the cornea, were assayed. The 8-oxo-dG and PDE groups showed marked improvements in corneal integrity and clarity when compared with the PBS group (each p p p
Databáze:	OpenAIRE
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