Human intervention study to investigate the intestinal accessibility and bioavailability of anthocyanins from bilberries
| Autor: | Dolores Mueller, Ralph Melcher, Kathrin Jung, Manuel Winter, Dorothee Rogoll, Elke Richling |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Colon Biological Availability Vaccinium myrtillus Absorption (skin) Urine Analytical Chemistry Anthocyanins 03 medical and health sciences medicine Humans Large intestine 030109 nutrition & dietetics Chromatography Plant Extracts Chemistry fungi Healthy subjects food and beverages Bilberry extract General Medicine Intervention studies Small intestine Bioavailability carbohydrates (lipids) medicine.anatomical_structure Food Science |
| Zdroj: | Food Chemistry. 231:275-286 |
| ISSN: | 0308-8146 |
| DOI: | 10.1016/j.foodchem.2017.03.130 |
| Popis: | We investigated the importance of the large intestine on the bioavailability of anthocyanins from bilberries in humans with/without a colon. Low bioavailability of anthocyanins in plasma and urine was observed in the frame of this study. Anthocyanins reached the circulation mainly as glucuronides. Analysis of ileal effluents (at end of small intestine) demonstrated that 30% of ingested anthocyanins were stable during 8h passage through the upper intestine. Only 20% degradants were formed and mostly intact anthocyanins were absorbed from the small intestine. Higher amounts of degradants than anthocyanins reached the circulation after bilberry extract consumption in both groups of subjects. Comparison of the bioavailability of anthocyanins in healthy subjects versus ileostomists revealed substantially higher amounts of anthocyanins and degradants in the plasma/urine of subjects with an intact gut. The results suggested that the colon is a significant site for absorption of bioactive components such as anthocyanins and their degradation products. |
| Databáze: | OpenAIRE |
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