Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size
| Autor: | Tamiko Ikeno, Atsuko Araki, Katsuyuki Murata, Chihiro Miyashita, Takashi Todaka, Jumboku Kajiwara, Reiko Kishi, Akira Yasutake, Noriyuki Hachiya, Seiko Sasaki, Tamie Nakajima, Sachiko Ito |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
China Environmental Engineering Birth weight chemistry.chemical_element Physiology Food Contamination In utero exposure Toxicology Fetal Development chemistry.chemical_compound Polychlorinated biphenyls Pregnancy medicine Environmental Chemistry Birth Weight Humans Waste Management and Disposal Methylmercury chemistry.chemical_classification Infant Newborn Small for gestational age Anthropometry Methylmercury Compounds medicine.disease Pollution Birth size Mercury (element) chemistry In utero Maternal Exposure Fatty Acids Unsaturated Environmental Pollutants Female Polyunsaturated fatty acids Polyunsaturated fatty acid |
| Zdroj: | Science of The Total Environment. 533:256-265 |
| ISSN: | 0048-9697 |
| Popis: | The adverse effects of in utero exposure to polychlorinated biphenyls (PCBs) or methylmercury (MeHg), and the beneficial effects of nutrients from maternal fish intake might have opposing influences on fetal growth. In this study, we assessed the effects of in utero exposure to PCBs and MeHg on birth size in the Japanese population, which is known to have a high frequency of fish consumption. The concentrations of PCBs and polyunsaturated fatty acids in maternal blood, and the total mercury in hair (as a biomarker of MeHg exposure) were measured during pregnancy and at delivery. Maternal intakes of fish (subtypes: fatty and lean) and shellfishes were calculated from a food frequency questionnaire administered at delivery. Newborn anthropometric measurement data were obtained from birth records. The associations between chemical exposures and birth size were analyzed by using multiple regression analysis with adjustment for confounding factors among 367 mother–newborn pairs. The birth weight was 3073 ± 37 g (mean ± SD). The incidence of babies small for gestational age (SGA) by weight was 4.9%. The median concentrations of total PCBs and hair mercury were 108 ng/g lipid and 1.41 μg/g, respectively. There was no overall association between mercury concentrations and birth weight, birth length, chest circumference, and head circumference. We observed that the risk of SGA by weight decreased with increasing mercury concentration in regression analyses with adjustment for polyunsaturated fatty acids. Our results suggest that the beneficial effect of essential nutrition may mask the adverse effects of MeHg on birth size. The concentrations of PCBs had no association with birth size. |
| Databáze: | OpenAIRE |
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