Immediate retrograde amnesia induced by midazolam: A prospective, non-randomised cohort study
| Autor: | Sun Woo Nam, Dongsik Lim, Hyo Seok Na, Hye Min Sohn, Sang Hwan Do, In Koung Yi, Jung-Won Hwang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Anterograde amnesia
genetic structures medicine.drug_class Sedation Midazolam Amnesia Cohort Studies Pregnancy mental disorders medicine Humans Hypnotics and Sedatives heterocyclic compounds Prospective Studies Prospective cohort study Benzodiazepine business.industry Retrograde amnesia General Medicine medicine.disease surgical procedures operative Sedative Anesthesia Amnesia Retrograde Female medicine.symptom business psychological phenomena and processes medicine.drug |
| Zdroj: | International journal of clinical practiceREFERENCES. 75(11) |
| ISSN: | 1742-1241 |
| Popis: | BACKGROUND Midazolam, a short-acting benzodiazepine, has sedative, anxiolytic, amnestic and anticonvulsant effects. Given its advantages of rapid onset, short duration and low toxicity, midazolam is optimal for any procedural sedation. Midazolam is known to cause anterograde amnesia; however, the possibility of retrograde amnesia has also been raised. This prospective cohort, non-randomised study evaluated the presence and extent of retrograde amnesia induced by midazolam during caesarean delivery. METHODS One hundred parturients scheduled for elective caesarean delivery under spinal anaesthesia were enrolled. As soon as giving birth, six picture cards were shown to the patients in 1-min intervals, and then midazolam (0.1 mg/kg) was given or not according to the patients' preference. This overall retrograde recall rate of six cards was the primary outcome of our study, which was asked by a blinded investigator. RESULTS The overall retrograde card recall rate was lower in the midazolam group compared with the control group (77.0 ± 13.4 vs. 87.7 ± 3.9%, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|