Diphenyl diselenide and cidofovir present anti-viral activity against Bovine Alphaherpesvirus 2 in vitro and in a sheep model

Autor:	L.M. Feio, Juliana Felipetto Cargnelutti, Ana Paula G. Mortari, Cristina W. Nogueira, Rudi Weiblen, Ingryd Merchioratto, Bruna Portolan Amaral, Eduardo Furtado Flores
Rok vydání:	2020
Předmět:	Foscarnet Drug 040301 veterinary sciences animal diseases viruses media_common.quotation_subject Sheep Diseases Antiviral Agents 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound Mammary Glands Animal Herpesvirus 2 Bovine Organoselenium Compounds medicine Benzene Derivatives Animals Diphenyl diselenide 030304 developmental biology media_common 0303 health sciences Sheep General Veterinary biology virus diseases Anti virals Herpes Simplex 04 agricultural and veterinary sciences biochemical phenomena metabolism and nutrition biology.organism_classification Virology In vitro Virus Shedding Bovine herpesvirus 2 chemistry Viral Activity Female Cidofovir medicine.drug
Zdroj:	Research in veterinary science. 134
ISSN:	1532-2661
Popis:	Bovine alphaherpesvirus 2 (BoHV-2) - the agent of bovine herpetic mamillitis (BHM) – is related to Human alphaherpesviruses 1 and 2 (HHV-1, HHV-2) and, as such, has been proposed as a model for vaccine and drug testing. We herein investigated the anti-viral activity in vitro against BoHV-2 of three anti-herpetic drugs: Cidofovir (CDV), Fanciclovir (FAM), Foscarnet (PFA), and diphenyl disselenide (Ph2Se2), a compound that has showed activity against HHV-2. Plaque reduction assays (PRA) revealed a significant reduction in viral plaques (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec46725f2169ebed71eb90a46869bb80 https://pubmed.ncbi.nlm.nih.gov/33338952 Zobrazit plný text záznamu Full Text from ScienceDirect