Updated Principles of Surgical Management of Pancreatic Neuroendocrine Tumours (pNETs): What Every Surgeon Needs to Know
| Autor: | Charles de Ponthaud, Fabrice Menegaux, Sébastien Gaujoux |
|---|---|
| Přispěvatelé: | Service de Chirurgie Générale, Viscérale et Endocrinienne [CHU Pitié-Sapêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Chirurgie Digestive, Hépato-Bilio-pancréatique et Transplantation Hépatique [CHU Pitié-Salpétrière] |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Surgical resection
Cancer Research medicine.medical_specialty medicine.medical_treatment [SDV.CAN]Life Sciences [q-bio]/Cancer Review 030230 surgery 03 medical and health sciences 0302 clinical medicine medicine RC254-282 business.industry General surgery Gold standard Advanced stage minimally invasive approach Neoplasms. Tumors. Oncology. Including cancer and carcinogens Pancreatic tumour parenchyma sparing pancreatectomy pancreatic neuroendocrine tumours 3. Good health Oncology Curative treatment 030220 oncology & carcinogenesis Radiological weapon lymphadenectomy Lymphadenectomy business |
| Zdroj: | Cancers, Vol 13, Iss 5969, p 5969 (2021) Cancers Cancers, MDPI, 2021, 13 (23), pp.5969. ⟨10.3390/cancers13235969⟩ |
| ISSN: | 2072-6694 |
| Popis: | Simple Summary In this narrative review, we update the surgical management of pancreatic neuroendocrine tumours (pNETs) and highlight key elements in view of the recent literature. These tumours are rare and suffer from a lack of data and randomized controlled trials. The pNETs management is difficult due to their heterogeneity and the risks associated with pancreatic surgery. Innovative managements such as “watch and wait” strategies, parenchymal sparing surgery and minimally invasive approach are emerging. The correct use of all these therapeutic options requires a good selection of patients but also a constant update of knowledge. Abstract Pancreatic neuroendocrine tumours (pNETs) represent 1 to 2% of all pancreatic neoplasm with an increasing incidence. They have a varied clinical, biological and radiological presentation, depending on whether they are sporadic or genetic in origin, whether they are functional or non-functional, and whether there is a single or multiple lesions. These pNETs are often diagnosed at an advanced stage with locoregional lymph nodes invasion or distant metastases. In most cases, the gold standard curative treatment is surgical resection of the pancreatic tumour, but the postoperative complications and functional consequences are not negligible. Thus, these patients should be managed in specialised high-volume centres with multidisciplinary discussion involving surgeons, oncologists, radiologists and pathologists. Innovative managements such as “watch and wait” strategies, parenchymal sparing surgery and minimally invasive approach are emerging. The correct use of all these therapeutic options requires a good selection of patients but also a constant update of knowledge. The aim of this work is to update the surgical management of pNETs and to highlight key elements in view of the recent literature. |
| Databáze: | OpenAIRE |
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