B-Type Natriuretic Peptide in Heart Failure With Preserved Ejection Fraction - Relevance to Age-Related Left Ventricular Modeling in Japanese
| Autor: | Hiroyuki Maeda, Yuji Mizuno, Makoto Shono, Koichiro Kuwahara, Hirofumi Yasue, Fumihito Kugimiya, Naotsugu Yano, Eisaku Harada |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Aging medicine.drug_class Population Diastole 030204 cardiovascular system & hematology 03 medical and health sciences Ventricular Dysfunction Left 0302 clinical medicine Sex Factors Internal medicine Natriuretic Peptide Brain Natriuretic peptide Medicine Humans education Aged Aged 80 and over Heart Failure education.field_of_study Ejection fraction Ventricular Remodeling business.industry Age Factors General Medicine Middle Aged medicine.disease Pulse pressure 030104 developmental biology Blood pressure Heart failure Cardiology Female Cardiology and Cardiovascular Medicine Heart failure with preserved ejection fraction business |
| Zdroj: | Circulation journal : official journal of the Japanese Circulation Society. 81(7) |
| ISSN: | 1347-4820 |
| Popis: | BACKGROUND Heart failure (HF) with preserved ejection fraction (HFpEF) is increasing with aging of the population. Plasma levels of B-type natriuretic peptide (BNP) increase in proportion to the severity of left ventricular (LV) dysfunction. The object of this study was to examine the plasma levels of BNP in HFpEF to better understand the pathogenesis of HFpEF as compared with HF with reduced EF (HFrEF).Methods and Results:The study subjects comprised 468 HFpEF patients (158 men, 310 women, mean age 81.3±9.6 years) and 126 HFrEF patients (77 men, 49 women, mean age 75.4±12.0 years) who underwent echocardiography and routine clinical examinations including plasma BNP. Age, female prevalence, systolic blood pressure and pulse pressure were higher in the HFpEF patients than in the HFrEF patients (P |
| Databáze: | OpenAIRE |
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