Vascular Lesions in Hypertensive Rats under Salt Loading: Kidney Renin and Lysosomal Enzymes
| Autor: | Noboru Saito, Chuichi Kawai, Koichi Ogino, Sakae Mukaino |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
medicine.medical_specialty Normal diet Cathepsin D Sodium Chloride Kidney Plasma renin activity Renal Veins Renal Artery Internal medicine medicine.artery Renin Renin–angiotensin system medicine Animals cardiovascular diseases Renal artery Mesenteric arteries Cerebral Hemorrhage Aorta business.industry General Medicine Mesenteric Arteries Rats medicine.anatomical_structure Endocrinology Hypertension cardiovascular system Female Lysosomes business |
| Zdroj: | Clinical Science. 51:49s-51s |
| ISSN: | 0144-4107 |
| DOI: | 10.1042/cs051049s |
| Popis: | 1. Renal and cerebral vascular lesions occurred more often and earlier in spontaneously hypertensive rats (SHR) given a high salt diet than in SHR given a normal diet. 2. Kidney renin activity was low during high salt loading; the kidney renin activity of rats with hypertensive renal vascular lesions was moderately elevated. Kidney renin activity or cathepsin D activities were higher in stroke-prone SHR (SHRSP) aged 9 months than in stroke-resistant SHR (SHRSR). 3. β-Glucuronidase, cathepsin D and deoxyribonuclease activities were greater in the kidney of Wistar/Kyoto (WK) rats or SHR when there were hypertensive vascular lesions. These three enzyme activities were also greater in the aorta of SHR aged 13–14 months than in the aorta of WK rats. 4. It was supposed that kidney renin activity and lysosomal enzyme activities were related to hypertensive vascular lesions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|