Inhibition of lyso-PAF: Acetyl-CoA acetyltransferase by salicylates and other compounds
| Autor: | Linda D. Faison, Helen L. White |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Neutrophils Benoxaprofen Diflunisal Biochemistry chemistry.chemical_compound Endocrinology Acetyltransferases Internal medicine medicine Animals Acetyl-CoA C-Acetyltransferase Platelet Activating Factor biology Platelet-activating factor Rats Inbred Strains Biological activity Salicylates Rats Nordihydroguaiaretic acid chemistry Acetyltransferase biology.protein Cyclooxygenase Salicylic acid medicine.drug |
| Zdroj: | Prostaglandins. 35:939-944 |
| ISSN: | 0090-6980 |
| DOI: | 10.1016/0090-6980(88)90117-7 |
| Popis: | Diflunisal and benoxaprofen (20–100 μM) produced dose-dependent inhibitions of lyso-platelet activating factor: acetyl-CoA acetyltransferase in a lysate of rat pleural neutrophils. Salicylate and aspirin were inhibitory at concentrations of 1 mM and above. Nordihydroguaiaretic acid was a relatively potent inhibitor (I 50 = 6 μ M). Other compounds, including anti-inflammatory steroids, cyclooxygenase and 5-lipoxygenase inhibitors, appeared ineffective at relevant concentrations. Inhibitions by diflunisal and salicylate occurred at concentrations similar to expected plasma levels in humans at therapeutic doses. An inhibitions of platelet-activating factor synthesis may contribute to the antiinflammatory, analgesic, or antipyretic actions of these compounds. |
| Databáze: | OpenAIRE |
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