A polymorphism of LOC387715 gene is associated with age-related macular degeneration in the Japanese population
| Autor: | T. Ue, H. Tamura, Hideshi Kawakami, Hirofumi Maruyama, S. Tanimoto, Yoshiaki Kiuchi, Ken Yamane |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Genetic Markers
Male Aging Genotype genetic structures Genetic Linkage DNA Mutational Analysis Disease White People Macular Degeneration Gene Frequency Japan Age related Humans Medicine Genetic Predisposition to Disease Genetic Testing Gene Aged Genetic association Aged 80 and over Genetics Polymorphism Genetic Chromosomes Human Pair 10 business.industry General Neuroscience Homozygote Chromosome Mapping Proteins Odds ratio Macular degeneration Japanese population medicine.disease eye diseases Complement Factor H Optometry Female sense organs business |
| Zdroj: | Neuroscience Letters. 414:71-74 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2006.12.011 |
| Popis: | Age-related macular degeneration (AMD) is one of the leading causes of blindness among older adults in developed countries and also in Japan. Previous research suggests that AMD is etiologically a complex disease, caused by multiple genes and environmental factors. Association studies have identified that a complement factor H gene (CFH) variant is a major risk factor for AMD in Caucasians. However, we and two other groups have reported no association between CFH and AMD in the Japanese population. Recent studies have suggested that LOC387715 on chromosome 10q26 may be the second major risk loci for AMD in Caucasians. In this study, we examined the association between LOC387715 and AMD in Japanese, and our results show that polymorphism of the LOC387715 gene is associated with AMD in Japanese as well as in Caucasians. Our data show a disease odds ratio of 6.20 (95% CI: 2.87-13.40) conferred by homozygosity for risk alleles at LOC387715 compared with the non-risk genotype. A polymorphism of LOC387715 gene is associated with AMD in the Japanese population. |
| Databáze: | OpenAIRE |
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