Expression of fibroblast growth factor 9 is associated with poor prognosis in patients with resected non-small cell lung cancer
| Autor: | Keiko Ohgino, Daisuke Arai, Takashi Sato, Junko Hamamoto, Tomoko Betsuyaku, Aoi Kuroda, Hiroyuki Yasuda, Tetsuo Tani, Shinnosuke Ikemura, Satoshi Yoda, Kenzo Soejima, Yuichiro Hayashi, Hideki Terai, Katsuhiko Naoki, Kota Ishioka |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Fibroblast Growth Factor 9 Male Pulmonary and Respiratory Medicine Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Microarray Pulmonary Surgical Procedures Fibroblast growth factor FGF9 Carcinoma Non-Small-Cell Lung Internal medicine Biomarkers Tumor medicine Humans Lung cancer Lung Aged Aged 80 and over Cell growth business.industry Middle Aged Microarray Analysis Prognosis medicine.disease Survival Analysis respiratory tract diseases stomatognathic diseases medicine.anatomical_structure Adenocarcinoma Immunohistochemistry Female business |
| Zdroj: | Lung Cancer. 83:90-96 |
| ISSN: | 0169-5002 |
| Popis: | Objectives Fibroblast growth factor (FGF) 9 is a member of the FGF family, which modulates cell proliferation, differentiation, and motility. Recent studies show that the activation of FGF signals including FGF9 is associated with the pathogenesis of several cancers; however, its clinicopathological and biological significance in non-small cell lung cancer (NSCLC) is unclear. The purpose of this study was to clarify the characteristics of NSCLC with FGF9 expression. Materials and Methods We evaluated the expression of FGF9 in resected NSCLC specimens and corresponding non-tumorous lung tissue samples using cDNA microarray and evaluated its clinicopathological characteristics. Results Nine out of 90 NSCLC specimens (10%) had "high" FGF9 expression compared with corresponding non-cancerous lung tissues. Histologically, of the 9 NSCLC specimens with high FGF9 expression, 5 were adenocarcinoma, whereas none were squamous cell carcinoma. FGF9 expression was not associated with sex, smoking history, or clinical stage. However, in patients with high and low FGF9 expression, the postoperative recurrence rates were 78% and 24% ( p =0.033), respectively. Overall survival was significantly shorter in patients with high FGF9 expression than in those with low FGF9 expression ( p Conclusion Our data indicate that FGF9 may be a novel unfavorable prognostic indicator and a candidate therapeutic target of NSCLC. |
| Databáze: | OpenAIRE |
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