Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
Autor: | Marc J. E. C. van der Maarel, Marco A. van den Berg, Steven Geysens, Etienne Danchin, Rachel M. van der Kaaij, Hein Stam, Jibin Sun, Kaj Albermann, Maurien M.A. Olsthoorn, Arnold J. M. Driessen, Frans M. Klis, Monika Schmoll, Gerald Hofmann, K. Pal, Thomas Guillemette, Bernard Henrissat, Johannes H. de Winde, David B. Archer, Coenie Goosen, Pedro M. Coutinho, Richard Albang, Michael Cornell, Jens Nielsen, Johannes Andries Roubos, Harrie J. Kools, Peter J.J. Van De Vondervoort, Cornelis Maria Jacobus Sagt, Noël Nicolaas Maria Elisabeth Van Peij, Jannick Dyrløv Bendtsen, Alard Van Dijk, Marga Herweijer, Martin Mortimer, Ursula Rinas, An-Ping Zeng, Roland Contreras, Holger Wedler, Stephen G. Oliver, Cees A. M. J. J. van den Hondel, David W. Ussery, Gert S.P. Groot, Jaap Visser, Mikael Rørdam Andersen, Arthur F. J. Ram, Hildegard Henna Menke, René T. J. M. van der Heijden, Paul S. Dyer, Piet W. J. de Groot, Han A. B. Wösten, Alfons J. M. Debets, Jacques A.E. Benen, János Varga, Lubbert Dijkhuizen, Christian P. Kubicek, Peter J. T. Dekker, Albert J. J. van Ooyen, Johannes Petrus Theodorus Wilhelmus Van Den Hombergh, Ronald P. de Vries, Rogier Meulenberg, Jürgen Lauber, Mark X. Caddick, Geoffrey Turner, Xin Lu, Patricia Ann van Kuyk, Wouter Vervecken, Peter J. Schaap, Piet W.M. van Dijck, Stefaan Breestraat, Herman Jan Pel, Christophe d'Enfert |
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Přispěvatelé: | DSM, Delft University of Technology (TU Delft), School of Biology, University of Nottingham, UK (UON), Technical University of Denmark [Lyngby] (DTU), Wageningen University and Research Centre (WUR), Department of Molecular Biology and Biotechnology, University of Sheffield [Sheffield], Utrecht University [Utrecht], Biomax Informatics AG, CLC bio, Partenaires INRAE, School of Biological Sciences, University of Liverpool, Universiteit Gent = Ghent University [Belgium] (UGENT), Flanders Institute for Biotechnology, University of Manchester [Manchester], Architecture et fonction des Macromolécules Biologiques - UMR 6098 (AFMB), Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Laboratory of Genetics, Wageningen University and Research [Wageningen] (WUR), University of Groningen, Biologie et Pathogénicité fongiques, Institut Pasteur [Paris]-Institut National de la Recherche Agronomique (INRA), Institut Pasteur [Paris], Centre for Carbohydrate Bioprocessing, VU University Amsterdam, Unité de recherche Pathologie végétale et phytobactériologie, Institut National de la Recherche Agronomique (INRA), Leiden University, Radboud University Medical Center [Nijmegen], Vienna University of Technology, Qiagen GmbH, Center for Microbial Biotechnology (CMB), University of Szeged, Helmholtz Centre for Infection Research (HZI), Center for Biological Sequence Analysis, Fungal Biodiversity Centre, Fungal Genetics and Technology Consultancy, Ministère de la Recherche : programme ACI-BCMS, Enzywall, Sonderforschungsbereich 578 (SFB578) of the Deutsche Forschungsgemeinschaft, Germany, Groningen Biomolecular Sciences and Biotechnology, Host-Microbe Interactions, Molecular Microbiology, Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Universiteit Gent = Ghent University (UGENT), Biologie et Pathogénicité fongiques (BPF), Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP), Vrije Universiteit Amsterdam [Amsterdam] (VU), Universiteit Leiden, University of Szeged [Szeged], Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), Sub Molecular Microbiology |
Jazyk: | angličtina |
Rok vydání: | 2007 |
Předmět: |
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
INDUSTRIAL APPLICATION autolysis dna Applied Microbiology and Biotechnology Genome Microbiologie Putative gene ENZYME TECHNOLOGY TRANSCRIPTION FACTOR Plant Proteins degradation 2. Zero hunger chemistry.chemical_classification 0303 health sciences biology filamentous fungi nidulans Chromosome Mapping unfolded protein response PE&RC SEQUENCE ANALYSIS GENE FUNCTION Biochemistry Molecular Medicine SECRETION saccharomyces-cerevisiae Laboratory of Genetics Chromosomes Fungal Genome Fungal Biotechnology reconstruction Bioinformatics Molecular Sequence Data Biomedical Engineering Bioengineering Stress Laboratorium voor Erfelijkheidsleer Microbiology DNA sequencing 03 medical and health sciences 030304 developmental biology Synteny VLAG Base Sequence ASPERGILLUS NIGER 030306 microbiology GENOMIC Protein Aspergillus niger Sequence Analysis DNA fumigatus biology.organism_classification Major facilitator superfamily Open reading frame Enzyme chemistry Cluster Cellular energy metabolism [UMCN 5.3] metabolism |
Zdroj: | Nature Biotechnology, 25(2), 221-231 Nature Biotechnology Nature Biotechnology, Nature Publishing Group, 2007, 25 (2), pp.221-231. ⟨10.1038/nbt1282⟩ Nature Biotechnology, 25(2), 221-231. Nature Publishing Group Nature Biotechnology, 2007, 25 (2), pp.221-231. ⟨10.1038/nbt1282⟩ Nature Biotechnology 25 (2007) Nature Biotechnology, 25, 221-31 Nature Biotechnology, 25, 2, pp. 221-31 Nature Biotechnology, 25, 221-231 Nature Biotechnology, 25(2), 221. Nature Publishing Group Technical University of Denmark Orbit |
ISSN: | 1087-0156 |
Popis: | Contains fulltext : 51722.pdf (Publisher’s version ) (Closed access) The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced the 33.9-megabase genome of A. niger CBS 513.88, the ancestor of currently used enzyme production strains. A high level of synteny was observed with other aspergilli sequenced. Strong function predictions were made for 6,506 of the 14,165 open reading frames identified. A detailed description of the components of the protein secretion pathway was made and striking differences in the hydrolytic enzyme spectra of aspergilli were observed. A reconstructed metabolic network comprising 1,069 unique reactions illustrates the versatile metabolism of A. niger. Noteworthy is the large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors, and the presence of putative gene clusters for fumonisin and ochratoxin A synthesis. |
Databáze: | OpenAIRE |
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