To what extent do the storage conditions of polyether‐based polyurethane have an impact on diazepam delivery?
| Autor: | Christine Barthélémy, Morgane Masse, Nicolas Blanchemain, Bertrand Décaudin, Stephanie Degoutin, Stéphanie Genay, Feng Chai, Aurélie Maiguy-Foinard, Pascal Odou |
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| Přispěvatelé: | Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 (GRITA), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Unité Matériaux et Transformations - UMR 8207 (UMET), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centrale Lille Institut (CLIL), Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 (MBLC - ADDS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille, Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
biomedical applications
Materials science Polymers and Plastics differential scanning calorimetry (DSC) 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology thermogravimetric analysis (TGA) 01 natural sciences 0104 chemical sciences Surfaces Coatings and Films chemistry.chemical_compound [CHIM.POLY]Chemical Sciences/Polymers Chemical engineering chemistry polyurethane Materials Chemistry medicine 0210 nano-technology Diazepam medicine.drug Polyurethane |
| Zdroj: | Journal of Applied Polymer Science Journal of Applied Polymer Science, Wiley, 2020, 137 (43), pp.49333. ⟨10.1002/app.49333⟩ Journal of Applied Polymer Science, 2020, 137 (43), pp.49333. ⟨10.1002/app.49333⟩ |
| ISSN: | 0021-8995 1097-4628 |
| DOI: | 10.1002/app.49333⟩ |
| Popis: | Interactions between medical device material and the drug itself have been evoked for polyurethane and may lead to underdosing. Polyurethane, sterilization mode, and the crosslinking level of the polymer have an influence on sorption. The aim here is to evaluate the impact of polyurethane conservation time and conditions as well as sterilization mode. Two polyurethane extension tubes were tested, one sterilized by ethylene oxide and the second by gamma radiation. Forced degradation experiments were performed. After 3 and 6 months of incubation, thermal properties, diazepam delivery and cytotoxicity of leachates were assessed. Diazepam delivery differs significantly according to the version of polyurethane. Sterilization however has no impact on diazepam delivery. No cytotoxicity was observed whatever the infusion tube and the aging conditions. In conclusion, sterilization procedures do not induce polyurethane degradation, but high temperature/relative humidity/time storage conditions lead to a slight degradation in polyurethane. |
| Databáze: | OpenAIRE |
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