Submandibular gland-conditioned medium enhancement of bone marrow colony-forming cells in tumor-bearing murine recipients
| Autor: | G. D. Ledney, D. F. Gruber |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
C57BL/6 Pathology medicine.medical_specialty Lung Neoplasms Lymphoma Submandibular Gland Population Bone Marrow Cells Andrology Mice Cellular and Molecular Neuroscience Colony-Stimulating Factors Pregnancy Leukocytes medicine Animals Neoplasm Progenitor cell education Clonogenic assay Molecular Biology Cells Cultured Pharmacology education.field_of_study biology Macrophages Carcinoma Uterus Lewis lung carcinoma Neoplasms Experimental Thymus Neoplasms Cell Biology Hematopoietic Stem Cells biology.organism_classification medicine.disease Submandibular gland Hematopoiesis Mice Inbred C57BL medicine.anatomical_structure Mice Inbred CBA Molecular Medicine Female Bone marrow Neoplasm Transplantation |
| Zdroj: | Experientia. 39:101-103 |
| ISSN: | 1420-9071 0014-4754 |
| DOI: | 10.1007/bf01960653 |
| Popis: | Soft-agar clonogenic assay techniques were used to examine 2 sources of colony-stimulating activity (CSA), submandibular gland-conditioned medium (SMG-CM) and pregnant mouse uterine extract (PMUE), for potentiation of granulocyte-macrophage (GM-CFUc) or monocyte-macrophage (M-CFUc) progenitor cell populations. The femoral populations being examined were aspirated from normal mice and from those bearing 1 of 2 types of tumor: Lewis lung carcinoma (3LL) or thymic lymphoma ascites tumor (EL-4). When PMUE was used as a CSA source, normal animals showed a greater clonogenic response per population than either of the tumor-bearing groups. When SMG-CM was used as a CSA source, the pattern of GM-CFUc response was much different: GM-CFUc magnitudes increased by fourfold to sixfold over normal levels in tumor-bearing animals. M-CFUc response patterns were also significant, being similar in response but smaller. |
| Databáze: | OpenAIRE |
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