Comparison of the Effects of Dexmedetomidine on the Induction of Anaesthesia Using Marsh and Schnider Pharmacokinetic Models of Propofol Target-Controlled Infusion
| Autor: | Mohamed Zaini Rh, Tan Hs, Wan Hassan Wmn |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
business.industry
Remifentanil General Medicine Intellectual content Target controlled infusion 03 medical and health sciences 0302 clinical medicine Pharmacokinetics 030202 anesthesiology Anesthesia medicine Original Article Dexmedetomidine Propofol business 030217 neurology & neurosurgery medicine.drug |
| Popis: | The study aimed to determine the effects of dexmedetomidine on the induction of anaesthesia using different models (Marsh and Schnider) of propofol target-controlled infusion (TCI).Sixty-four patients aged 18-60 years, American Society of Anaesthesiologists (ASA) class I-II who underwent elective surgery were randomised to a Marsh group (The Ct for successful induction in the Schnider group was significantly lower than in the Marsh group (3.48 [0.90] versus 4.02 [0.67] μg/mL;In the between-group comparison, dexmedetomidine reduced the Ct requirement for induction and shortened the induction time in the Schnider group. The inclusion of baseline groups without dexmedetomidine in a four-arm comparison of the two models would enhance the validity of the findings. |
| Databáze: | OpenAIRE |
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