Protective role of pentobarbital pretreatment for NMDA-R activated lipid peroxidation is derived from the synergistic effect on endogenous anti-oxidant in the hippocampus of rats
| Autor: | Akira Nakajima, Yuto Ueda, Keiko Nagatomo, Taku Doi |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Pentobarbital Free Radicals Neurotoxins Hippocampus Endogeny Pharmacology Hippocampal formation Receptors N-Methyl-D-Aspartate Neuroprotection Antioxidants Lipid peroxidation chemistry.chemical_compound Excitatory Amino Acid Agonists medicine Animals Hypnotics and Sedatives Rats Wistar General Neuroscience Rats Oxidative Stress Neuroprotective Agents chemistry Blood-Brain Barrier Hypoxia-Ischemia Brain Anesthetic NMDA receptor Lipid Peroxidation Neuroscience medicine.drug |
| Zdroj: | Neuroscience Letters. 417:46-49 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2007.02.031 |
| Popis: | We have attempted to explore the neuroprotective effectiveness of PBT by measuring anti-oxidant ability in the hippocampus of rats in a freely moving state. Anti-oxidant ability was examined utilizing the principle that blood–brain barrier-permeable nitroxide radicals (PCAM) injected i.p. lose their paramagnetism in an exponential decay correlated with anti-oxidant ability in the brain. The half-life of PCAM was used as the indicator of the hippocampal anti-oxidant ability. While the half-life was statistically prolonged when infused with 0.1 mM NMDA without PBT, the half-life was almost the same as in the control when infused with NMDA under anesthesia with PBT. In addition, the half-life under only PBT anesthesia was the shortest of all the groups. Our findings, therefore, suggested that PBT anesthesia not only suppresses NMDA-R activated free radical generation but also synergistically enhances the increased basal endogenous anti-oxidant ability in the hippocampus. |
| Databáze: | OpenAIRE |
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