Serum dioxin-like activity is associated with reproductive parameters in young men from the general Flemish population
| Autor: | Dhooge, Willem, Van Larebeke, Nicolas, Koppen, Gudrun, Nelen, Vera, Schoeters, Greet, Vlietinck, Robert, Kaufman, Jean Marc, Comhaire, Frank, Buntinx, F., Callens, S., Den Hond, E., Fagard, R., Nawrot, T., Thijs, L., Staessen, J. A., Vanderschueren, D., Van Hecke, E., Van Loon, H., Viaene, M. K., De Ceuster, T., Goelen, E., Van Den Heuvel, R., Verheyen, G., Verschaeve, L., Loots, I., Herremans, M., Mertens, P., Vermeire, P., Weyler, J., Roels, H. A. |
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| Přispěvatelé: | Buntinx, Frank, Callens, Stefaan, Fagard, Robert, Nawrot, Tim, Staessen, Jan, Thijs, Lutgarde, Van Hecke, Etienne, Vanderschueren, Dirk, Verheyen, Geert, Analytical, Environmental & Geo-Chemistry, Chemistry, Biology, Faculty of Law and Criminology, Faculty of Economic and Social Sciences and Solvay Business School, Faculty of Sciences and Bioengineering Sciences, Faculty of Physical Education and Physical Therapy, UZB Other, Faculty of Medicine and Pharmacy, Faculty of Psychology and Educational Sciences, Department of Bio-engineering Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
TCDD BIPHENYLS Health Toxicology and Mutagenesis Developmental toxicity Toxicology egg consumption male fertility Follicle-stimulating hormone Sex hormone-binding globulin Belgium Sex Hormone-Binding Globulin TESTOSTERONE Medicine and Health Sciences INFERTILE MEN heterocyclic compounds Receptor reproductive and urinary physiology Testosterone Public Environmental & Occupational Health education.field_of_study Estradiol Sperm Count biology MALE-RATS HUMANS semen volume Male fertility PERSISTENT ORGANOCHLORINES Environmental Pollutants Life Sciences & Biomedicine Adult endocrine system medicine.medical_specialty Semen volume DR-CALUX Population Environmental Sciences & Ecology Dioxins Cell Line Tumor Internal medicine medicine Animals Humans 2 3 7 8-TETRACHLORODIBENZO-P-DIOXIN Inhibins Egg consumption EXPOSURE education SEMINAL-VESICLE POLYCHLORINATED AROMATIC-HYDROCARBONS Science & Technology hormones Research sperm concentration Public Health Environmental and Occupational Health Luteinizing Hormone dioxin Aryl hydrocarbon receptor Diet Rats stomatognathic diseases Endocrinology Receptors Aryl Hydrocarbon testosterone SEMEN QUALITY biology.protein Follicle Stimulating Hormone Biomarkers Environmental Sciences Hormone |
| Zdroj: | ENVIRONMENTAL HEALTH PERSPECTIVES Environmental Health Perspectives |
| ISSN: | 0091-6765 |
| Popis: | BACKGROUND: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and some related environmental contaminants are aryl hydrocarbon receptor (AhR) ligands that exert reproductive and developmental toxicity in laboratory animals. In humans, fertility-related effects are less documented. OBJECTIVE: The aim of this study was to investigate the relationship between dioxin-like biological activity in serum and parameters of reproductive status in men from the general population 5 months after a polychlorinated biphenyl and dioxin food-contamination episode in Belgium. DESIGN: In the framework of the cross-sectional Flemish Environment and Health Study (FLEHS), we recruited 101 men 20-40 years of age and evaluated sperm parameters, measured sex hormones, and gathered information on a number of lifestyle factors. In addition, we determined the AhR-mediated enzymatic response elicited by individual serum samples and expressed it as TCDD equivalent concentrations (CALUX-TEQs) using an established transactivation assay. RESULTS: Age (p = 0.04) and the frequency of fish (p = 0.02) and egg (p = 0.001) consumption were independent positive determinants of serum dioxin-like activity. After correcting for possible confounders, we found that a 2-fold increase in CALUX-TEQ > 16 pg/L was associated with a 7.1% and 6.8% (both p = 0.04) decrease in total and free testosterone, respectively. We also observed a more pronounced drop in semen volume of 16.0% (p = 0.03), whereas sperm concentration rose by 25.2% (p = 0.07). No relationship was found with total sperm count or sperm morphology. CONCLUSIONS: These data suggest an interaction of dioxin-like compounds with the secretory function of the seminal vesicles or prostate, possibly indirectly through an effect on testosterone secretion, at levels not affecting spermatogenesis as such. ispartof: Environ Health Perspect vol:114 issue:11 pages:1670-1676 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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