Intrathecal morphine and clonidine for coronary artery bypass grafting
| Autor: | P. Lena, J. Teboul, N. Balarac, J. J. Arnulf, F. Bonnet |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Agonist medicine.medical_specialty Time Factors medicine.drug_class Visual analogue scale Clonidine Bolus (medicine) Double-Blind Method Humans Medicine General anaesthesia Derivation Coronary Artery Bypass Injections Spinal Aged Aged 80 and over Analgesics Pain Postoperative Morphine business.industry Analgesia Patient-Controlled Middle Aged Surgery Cardiac surgery Analgesics Opioid Anesthesiology and Pain Medicine Anesthesia Drug Therapy Combination Female business medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 90:300-303 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/aeg070 |
| Popis: | Background After cardiac surgery adequate postoperative analgesia is necessary. We assessed analgesia using intrathecal morphine and clonidine. Methods In a double-blind randomized study, 45 patients having coronary artery bypass graft surgery were allocated randomly to receive i.v. patient-controlled analgesia (PCA) morphine (bolus, 1 mg; lock-out interval, 7 min) (control group), either alone or combined with intrathecal morphine 4 μg kg −1 or with both intrathecal morphine 4 μg kg −1 and clonidine 1 μg kg −1 . Intrathecal injections were performed before the induction of general anaesthesia. Pain was measured after surgery using a visual analogue scale (VAS). We recorded i.v. PCA morphine consumption during the 24 h after operation. Results Morphine dosage [median (25th–75th percentiles)] was less in the first 24 h in the patients who were given intrathecal morphine + clonidine [7 (0–37) mg] than in other patients [40.5 (15–61.5) mg in the intrathecal morphine group and 37 (30.5–51) mg in the i.v. morphine group]. VAS scores were lower after intrathecal morphine + clonidine compared with the control group. Time to extubation was less after intrathecal morphine + clonidine compared with the i.v. morphine group [225 (195–330) vs 330 (300–360) min, P Conclusion Intrathecal morphine and clonidine provide effective analgesia after coronary artery bypass graft surgery and allow earlier extubation. |
| Databáze: | OpenAIRE |
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