Diagnostic differences in respiratory breathing patterns and work of breathing indices in children with Duchenne muscular dystrophy

Autor: Tariq Rahman, Lauren Ryan, Abigail Strang, Robert Heinle, Thomas H. Shaffer
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Heredity
Pulmonology
Physiology
Genetic Linkage
Pulmonary Function
Duchenne Muscular Dystrophy
Muscular Dystrophies
Pulmonary function testing
Families
0302 clinical medicine
Heart Rate
Outpatients
Medicine and Health Sciences
Medicine
Respiratory inductance plethysmography
Child
Musculoskeletal System
Children
Tidal volume
Work of Breathing
Multidisciplinary
Respiration
3. Good health
Respiratory Function Tests
Plethysmography
Neurology
Breathing
X-Linked Traits
Sex Linkage
Child
Preschool
Cardiology
Anatomy
Infants
Research Article
medicine.medical_specialty
Respiratory rate
Patients
Adolescent
Science
Ribs
Respiratory physiology
03 medical and health sciences
Work of breathing
Respiratory Rate
Internal medicine
Heart rate
Genetics
Humans
Respiratory Physiology
Skeleton
Clinical Genetics
business.industry
Biology and Life Sciences
Health Care
Muscular Dystrophy
Duchenne
030228 respiratory system
Age Groups
Case-Control Studies
People and Places
Respiratory Mechanics
Population Groupings
business
Physiological Processes
030217 neurology & neurosurgery
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 1, p e0226980 (2020)
ISSN: 1932-6203
Popis: RationalePulmonary function testing (PFT) provides diagnostic information regarding respiratory physiology. However, many forms of PFT are time-intensive and require patient cooperation. Respiratory inductance plethysmography (RIP) provides thoracoabdominal asynchrony (TAA) and work of breathing (WOB) data. pneuRIPTM is a noninvasive, wireless analyzer that provides real-time assessment of RIP via an iPad. In this study, we show that pneuRIPTM can be used in a hospital clinic setting to differentiate WOB indices and breathing patterns in children with DMD as compared to age-matched healthy subjects.MethodsRIP using the pneuRIPTM was conducted on 9 healthy volunteers and 7 DMD participants (ages 5-18) recruited from the neuromuscular clinic, under normal resting conditions over 3-5 min during routine outpatient visits. The tests were completed in less than 10 minutes and did not add excessive time to the clinic visit. Variables recorded included labored-breathing index (LBI), phase angle (Φ) between abdomen and rib cage, respiratory rate (RR), percentage of rib cage input (RC%), and heart rate (HR). The data were displayed in histogram plots to identify distribution patterns within the normal ranges. The percentages of data within the ranges (0≤ Φ ≤30 deg.; median RC %±10%; median RR±5%; 1≤LBI≤1.1) were compared. Unpaired t-tests determined significance of the data between groups.Results100% patient compliance demonstrates the feasibility of such testing in clinical settings. DMD patients showed a significant elevation in Φ, LBI, and HR averages (PConclusionIn this study, noninvasive pneuRIPTM testing provided instantaneous PFT diagnostic results. As compared to healthy subjects, patients with DMD showed abnormal results with increased markers of TAA, WOB indices, and different breathing patterns. These results are similar to previous studies evaluating RIP in preterm infants. Further studies are needed to compare these results to other pulmonary testing methods. The pneuRIPTM testing approach provides immediate diagnostic information in outpatient settings.
Databáze: OpenAIRE
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