Siderophore–drug complexes: potential medicinal applications of the ‘Trojan horse’ strategy
| Autor: | Agnieszka Górska, Anna Sloderbach, Michał Piotr Marszałł |
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| Rok vydání: | 2014 |
| Předmět: |
Drug
Siderophore medicine.drug_class Iron media_common.quotation_subject Antibiotics Siderophores Drug resistance Toxicology Microbiology Drug Delivery Systems Gram-Negative Bacteria medicine Humans media_common Pharmacology biology business.industry Trojan horse Biological Transport biology.organism_classification Antimicrobial Anti-Bacterial Agents Biotechnology business Bacterial outer membrane Bacteria |
| Zdroj: | Trends in Pharmacological Sciences. 35:442-449 |
| ISSN: | 0165-6147 |
| Popis: | The ability of bacteria to develop resistance to antimicrobial agents poses problems in the treatment of numerous bacterial infections. One method to circumvent permeability-mediated drug resistance involves the employment of the 'Trojan horse' strategy. The Trojan horse concept involves the use of bacterial iron uptake systems to enter and kill bacteria. The siderophore-drug complex is recognized by specific siderophore receptors and is then actively transported across the outer membrane. The recently identified benefits of this strategy have led to the synthesis of a series of siderophore-based antibiotics. Several studies have shown that siderophore-drug conjugates make it possible to design antibiotics with improved cell transport and reduce the frequency of resistance mutants. Growing interest in siderophore-drug conjugates for the treatment of human diseases including iron overload, cancer, and malaria has driven the search for new siderophore-drug complexes. This strategy may have special importance for the development of iron oxide nanoparticle-based therapeutics. |
| Databáze: | OpenAIRE |
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