Distribution of Cervicocephalic Atherosclerotic Lesions and Their Correlation with Cardiovascular Risk Factors in a Population of Amerindians. The Atahualpa Project

Autor: Pragnesh R. Parikh, Gautam Matcha, Pablo R. Castillo, Juan A. Nader, Robertino M. Mera, Leslie V. Simon, Oscar H. Del Brutto, Verónica Espinosa, Mauricio Zambrano
Rok vydání: 2018
Předmět:
Carotid Artery Diseases
Male
medicine.medical_specialty
Population
Cardiovascular risk factors
Rural Health
030204 cardiovascular system & hematology
Carotid Intima-Media Thickness
Carotid siphon
Correlation
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Multidetector Computed Tomography
Odds Ratio
Humans
Medicine
cardiovascular diseases
Vascular Calcification
education
Aged
education.field_of_study
Chi-Square Distribution
business.industry
Indians
South American
Rehabilitation
Middle Aged
Intracranial Arteriosclerosis
Plaque
Atherosclerotic
Population based study
Logistic Models
Intima-media thickness
Multivariate Analysis
Linear Models
cardiovascular system
Cardiology
Female
Surgery
High calcium
Ecuador
Neurology (clinical)
Intracranial Atherosclerosis
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Zdroj: Journal of Stroke and Cerebrovascular Diseases. 27:3356-3364
ISSN: 1052-3057
DOI: 10.1016/j.jstrokecerebrovasdis.2018.07.043
Popis: No information is available on the distribution of cervicocephalic atherosclerosis in Amerindians. We aimed to assess the distribution of these lesions and their correlation with cardiovascular risk factors in Amerindians living in rural Ecuador.Atahualpa residents aged ≥40years underwent head CT for assessment of carotid siphon calcifications (CSC) and sonographic examination for measurement of the carotid intima media thickness (cIMT). CSC were used as a surrogate of intracranial atherosclerosis and the cIMT as a surrogate of extracranial atherosclerosis. Linear regression and multinomial logistic regression models were fitted to assess the association between cIMT and CSC, and to evaluate differences in risk factors across individuals with atherosclerosis involving both arterial beds when compared with those with extra- or intracranial atherosclerosis alone, or no atherosclerosis.Of 590 participants, 145 had high calcium content in the carotid siphons and 87 had a cIMT1mm (25% versus 15%, P.001). Thirty-eight (7%) individuals had atherosclerosis at both vascular beds, 107 (18%) had intracranial atherosclerosis, and 49 (8%) had extracranial atherosclerosis alone. The cIMT and CSC were independently associated (P = .008). When compared with participants without atherosclerosis, those with atherosclerosis at both vascular beds were older, more often male, hypertensive and diabetic. Subjects with intracranial atherosclerosis alone were older, and those with extracranial atherosclerosis alone reported less physical activity than those without atherosclerosis.Intracranial atherosclerosis is more common than extracranial atherosclerosis in Amerindians. Traditional risk factors only explain a minority of cases of cervicocephalic atherosclerosis in this population.
Databáze: OpenAIRE
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