Pretreatment with ablative fractional carbon dioxide laser improves treatment efficacy in a synergistic PDT protocol for actinic keratoses on the head
| Autor: | Lutz Schmitz, K. Dicke, V. Dervenis, Thomas Dirschka, C. Falkenberg, Rolf-Markus Szeimies |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Visual analogue scale medicine.medical_treatment 030303 biophysics Biophysics Urology Photodynamic therapy Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Ablative case medicine Humans Pharmacology (medical) 0303 health sciences Photosensitizing Agents business.industry Pulse (signal processing) Actinic keratosis Aminolevulinic Acid Carbon dioxide laser medicine.disease Treatment efficacy Keratosis Actinic Blood pressure Treatment Outcome Oncology Photochemotherapy Lasers Gas Triazenes business |
| Zdroj: | Photodiagnosis and photodynamic therapy. 34 |
| ISSN: | 1873-1597 |
| Popis: | BACKGROUND A recently proposed synergistic photodynamic therapy protocol (s-PDT) combining advantages of both conventional- and daylight-PDT proved to be an effective and almost painless treatment for patients with actinic keratoses (AKs). This study investigated the safety and efficacy of an additional ablative fractional CO2-laser (AFXL) pretreatment. METHODS 28 patients with AKs on the head received s-PDT using 5-aminolevulinic acid. AFXL pretreatment was conducted using the following parameters: pulse energy 8 mJ, spot density 50 spots/cm2, power 30 W, beam size 4-18 mm. Outcome was assessed by AK area and severity index (AKASI) and lesion count (LC) before and 3 months after treatment. Safety was monitored by blood pressure and pulse measurements. Intensity of pain was determined by use of a visual analog scale (VAS). RESULTS Most patients (96.4 %) showed a significant AKASI reduction (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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