Biological behavior of nanoparticles with Zr-89 for cancer targeting based on their distinct surface composition
| Autor: | Jun Young Lee, Seung Dae Yang, Jeong-Hoon Park, Pyeong Seok Choi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Surface Properties
media_common.quotation_subject Biomedical Engineering Iron oxide Nanoparticle Metal Nanoparticles Antineoplastic Agents chemistry.chemical_compound Mice Drug Delivery Systems Cell Line Tumor medicine Animals General Materials Science Tissue Distribution Internalization media_common chemistry.chemical_classification Radioisotopes Nanocomposite Polyvinylpyrrolidone Chemistry technology industry and agriculture General Chemistry General Medicine Polymer Neoplasms Experimental Surface coating RAW 264.7 Cells Chemical engineering Positron-Emission Tomography Cancer cell Adsorption Zirconium medicine.drug |
| Zdroj: | Journal of materials chemistry. B. 9(39) |
| ISSN: | 2050-7518 |
| Popis: | Nano-sized materials with properties that enable their internalization into target cells using passive targeting systems have been utilized with radioisotopes to track their pharmacokinetics in the body. Here, we report the incorporation of novel chelator-free Zr-89 using a hierarchical iron oxide nanocomposite (89Zr-IONC). Characterization revealed that it had a rice-shape with a mean width of 160 nm. The surface of the 89Zr-IONCs was coated by polyethyleneimine (PEI) and polyvinylpyrrolidone (PVP) to improve the cancer target efficacy. The biological behavior of the nanoparticles coated with the polymers differed significantly by the surface composition. Positron emission tomography measurements by the labeled Zr-89 effectively confirmed the cancer target capability and the fate of distribution in the body. We found that only PVP coated 89Zr-IONC reached the tumor region while non-coated and PEI coated 89Zr-IONC tended to be undesirably entirely cleared in the liver and spleen. The 89Zr-incorporated iron oxide nanocomposite is significantly stable for radiolabeling despite various surface modifications, allowing the potential carrier to specifically target cancer cells. The strategy of utilizing the biocompatible PEI and PVP surface coating system for negative charged nanoparticles such as iron oxide will afford enhanced biological application. |
| Databáze: | OpenAIRE |
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