Endothelin type A receptor antagonist attenuates placental ischemia–induced hypertension and uterine vascular resistance
| Autor: | Joshua S. Speed, Kiran Tam Tam, James N. Martin, Babbette LaMarca, Kathy Cockrell, Joey P. Granger, Eric M. George, Marietta Arany |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Endothelin Receptor Antagonists
medicine.medical_specialty Mean arterial pressure Pyrrolidines medicine.drug_class Placenta Ischemia Blood Pressure Article Preeclampsia Rats Sprague-Dawley Pregnancy Internal medicine medicine.artery medicine Animals Uterine artery reproductive and urinary physiology Ultrasonography business.industry Obstetrics and Gynecology medicine.disease Receptor antagonist Rats Disease Models Animal Uterine Artery medicine.anatomical_structure Endocrinology Blood pressure Atrasentan Hypertension Vascular resistance Female Vascular Resistance Endothelin receptor business Blood Flow Velocity |
| Popis: | Objective We sought to determine the effect of an endothelin type A receptor antagonist (ETA) on uterine artery resistive index (UARI) and mean arterial pressure (MAP) in a placental ischemia rat model of preeclampsia produced by reduction in uterine perfusion pressure (RUPP). Study Design UARI was assessed by Doppler velocimetry in RUPP and normal pregnant controls (NP) on gestational days (GD) 12, 15, and 18. UARI was also determined on GD 18 in NP and RUPP pregnant dams after pretreatment with ETA. MAP was recorded on GD 19. Results The RUPP group had a higher MAP and UARI on GD 15 and 18 than the NP group. Pretreatment with ETA attenuated both the MAP and GD-18 UARI in the RUPP group without affecting these parameters in the NP group. Conclusion The improvement in UARI could be one potential mechanism for the reduction in MAP in response to ETA in pregnant dams with ischemic placentas. |
| Databáze: | OpenAIRE |
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