Primary Hepatic Burkitt Lymphoma in a Kidney Transplant Recipient
| Autor: | Athina Androulaki, George Zavos, Sophia Lionaki, John Boletis, Eystratios Tsakonas, George Liapis, P Panayiotidis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Azathioprine Case Report lcsh:RC870-923 Gastroenterology Sepsis 03 medical and health sciences 0302 clinical medicine Internal medicine hemic and lymphatic diseases Biopsy medicine Kidney transplantation Past medical history medicine.diagnostic_test business.industry medicine.disease lcsh:Diseases of the genitourinary system. Urology 3. Good health Lymphoma medicine.anatomical_structure Nephrology 030220 oncology & carcinogenesis Toxicity 030211 gastroenterology & hepatology Bone marrow business medicine.drug |
| Zdroj: | Case Reports in Nephrology, Vol 2018 (2018) Case Reports in Nephrology |
| ISSN: | 2090-6641 |
| Popis: | This is a case of a renal transplant recipient who developed a primary hepatic Burkitt lymphoma a few years after kidney transplantation. The past medical history of the patient was significant for anti-HCV positivity with liver histopathology showing minimal changes of grades 0 and 1, stage 0. She received a graft from a deceased donor, with rabbit antithymocyte globulin and methyl-prednisolone, as induction therapy, and was maintained on azathioprine, cyclosporine, and low dose methyl-prednisolone with normal renal function. Four years after KTx she presented with fatigue, hepatomegaly, and impaired liver function and the workup revealed multiple, variable-sized, low density nodules in the liver, due to diffuse monotonous infiltration of highly malignant non-Hodgkin lymphoma of B-cells, which turned out to be a Burkitt lymphoma. Bone marrow biopsy and spinal fluid exam were free of lymphoma cells. At time of lymphoma diagnosis she was shown to be positive for Epstein-Barr virus polymerase chain reaction. She received aggressive chemotherapy but died due to sepsis, as a result of toxicity of therapy. |
| Databáze: | OpenAIRE |
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