Helicobacter pylori infection is strongly associated with gastric and duodenal ulcers in a large prospective study
| Autor: | Ben Schöttker, Melanie N. Weck, Mariam Abdullahi Adamu, Hermann Brenner |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Gastroenterology Risk Assessment Helicobacter Infections Cohort Studies Internal medicine Germany Surveys and Questionnaires Medicine CagA Humans Longitudinal Studies Prospective Studies Stomach Ulcer Risk factor Prospective cohort study Aged Hepatology biology Helicobacter pylori business.industry Stomach Incidence (epidemiology) Incidence Odds ratio Middle Aged biology.organism_classification Antibodies Bacterial digestive system diseases medicine.anatomical_structure Cross-Sectional Studies Duodenal Ulcer Female business Cohort study |
| Zdroj: | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 10(5) |
| ISSN: | 1542-7714 |
| Popis: | Background & aims Infection with Helicobacter pylori ( H pylori ) is a risk factor for peptic ulcer disease (PUD), but there are limited longitudinal data on the associations between infection and incident gastric or duodenal ulcers. Methods Information on potential risk factors, lifetime history of PUD, and serologic measurements of H pylori infection were obtained from a German cohort of 9953 adults, 50 to 74 years old at baseline (2000–2002). The incidence of ulcers was determined by questionnaires sent to study participants and general practitioners 2 and 5 years later, and was validated by medical records. Results A lifetime history of PUD was reported by 1030 participants, and during the follow-up period 48 had a first gastric and 22 had a first duodenal ulcer. Infection with H pylori strains that express cytotoxin-associated gene A ( cagA ) was significantly associated with a lifetime history of PUD (odds ratio, 1.75; 95% confidence interval [CI], 1.50–2.04). Based on longitudinal analyses with physician-validated end points, the adjusted hazard ratios for incident gastric and duodenal ulcer disease were 2.9 (95% CI, 1.5–5.5) and 18.4 (95% CI, 4.2–79.9), respectively, among patients infected with cagA -positive strains of H pylori . Conclusions In cross-sectional analysis, infection with cagA-positive strains of H pylori was associated with a 1.75-fold increased risk of peptic ulcer disease. Longitudinal analyses revealed an 18.4- and 2.9-fold increased risk for duodenal ulcer and gastric ulcer, respectively. The proportion of PUD that is attributable to H pylori infection might be larger than previously believed. |
| Databáze: | OpenAIRE |
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