Incidence of malignancy in a Spanish cohort of patients infected by the human immunodeficiency virus
| Autor: | Joaquin Burgos, Jordi Navarro, Berta Raventós, Adria Curran, Mario Martin-Castillo, Jorge García, Esperanza Cañas-Ruano, Vicenç Falcó, Esteban Ribera, Paula Suanzes |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Population HIV Infections 03 medical and health sciences 0302 clinical medicine Neoplasms Internal medicine medicine Humans 030212 general & internal medicine Lung cancer education Sarcoma Kaposi Retrospective Studies education.field_of_study business.industry Incidence Incidence (epidemiology) Mortality rate HIV Cancer Retrospective cohort study medicine.disease Cancer registry Spain Cohort Female business |
| Zdroj: | Medicina Clínica (English Edition). 155:288-294 |
| ISSN: | 2387-0206 |
| Popis: | A higher incidence of malignancies has been described in patients with HIV infection compared to the general population.Observational retrospective study in patients with HIV infection followed up at the Vall d'Hebron University Hospital (Barcelona, Spain) between 2009 and 2017. The objective of this research was to estimate the incidence of malignancies in HIV patients and their surveillance. Age and sex-adjusted incidence was compared to the incidence calculated by the Spanish Cancer Registry network (REDECAN) in 2015.We included 2,773 patients (41,238 patients-year). Two hundred and eleven malignancies were diagnosed in 182 patients. Non-AIDS defining cancers accounted for 78.2% of the malignancies. The global incidence of cancer was 485 cases per 100,000 person-years. Twenty-year mortality rate was 31.2% in patients with cancer and 7.8% in patients without cancer. In men, adjusted for age, the incidence of malignancies was higher than the incidence in the general population (978.4 vs. 641 cases per 100,000 person-years, P.001). The most common malignancies in men were lung cancer, Kaposi sarcoma and Hodgkin lymphoma. In women, the incidence of malignancies was not higher than in the general population (340.6 vs. 404.7 cases per 100,000 person-years, P=.27). The most common malignancies among women were lung cancer, head and neck cancer, cervical cancer and Hodgkin's lymphoma.Men with HIV infection showed a statistically significant higher incidence of malignancies compared to the general Spanish population. Lung cancer was the most common non-AIDS defining cancer. |
| Databáze: | OpenAIRE |
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