Efficacy of Levetiracetam in Electrical Status Epilepticus During Sleep of Children: A Multicenter Experience
| Autor: | Xi Chen, Zhi-Xian Yang, Li-Ping Zou, Shao-Ping Huang, Fang-Cheng Cai, Meng Zhao, Xiao-Qiao Chen, Bao-Dong Pang, Li Gao, Wei-Na Zhang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Levetiracetam Time Factors Status epilepticus Electroencephalography Epilepsy Status Epilepticus Developmental Neuroscience Seizures medicine Humans Child Retrospective Studies Seizure frequency medicine.diagnostic_test business.industry Neuropsychology Brain medicine.disease Magnetic Resonance Imaging Piracetam Sleep in non-human animals Treatment period Treatment Outcome Neurology Child Preschool Anesthesia Pediatrics Perinatology and Child Health Anticonvulsants Female Neurology (clinical) medicine.symptom Sleep business Follow-Up Studies medicine.drug |
| Zdroj: | Pediatric Neurology. 50:243-249 |
| ISSN: | 0887-8994 |
| DOI: | 10.1016/j.pediatrneurol.2013.10.015 |
| Popis: | Background Electrical status epilepticus during sleep is characterized by epilepsy, a specific electroencephalographic pattern, and neuropsychological impairment. This study aims to evaluate the efficacy and safety of levetiracetam in treating children with electrical status epilepticus during sleep. Methods A multicenter, retrospective, open-label study enrolled 73 children (mean age: 8 years) affected by electrical status epilepticus during sleep. The efficacy was rated according to the seizure frequency and electroencephalography response. Results After a mean treatment period of 19 months (range: 6 to 24 months), 33 (63.5%) of 52 patients became seizure-free or had experienced remarkable reduction in seizures. The electrical status epilepticus of 41 (56.2%) of 73 patients disappeared off their electroencephalography. The electroencephalography efficacy of levetiracetam treatment was noted in the monotherapy (61.9%) and add-on (53.9%) groups. The clinical (67.7%) and electroencephalography (64.3%) response rates of the idiopathic group were better than those of the symptomatic group (57.1% and 45.2%, respectively). No patient discontinued the trial because of intolerability of side effects. Conclusions Levetiracetam is effective in individuals with electrical status epilepticus during sleep with tolerable side effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect