Biogenic metallic elements in the human brain?
| Autor: | Kharmen Billimoria, James Everett, Xiongwei Zhu, Peter B. O’Connor, Ian Hands-Portman, Germán Plascencia-Villa, Vindy Tjendana-Tjhin, Neil D. Telling, Jake Brooks, Frederik Lermyte, George Perry, Joanna F. Collingwood, Jane M. Donnelly, Peter J. Sadler |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oxide
chemistry.chemical_element Neuropeptide Q1 complex mixtures Metal chemistry.chemical_compound medicine Research Articles Brain function Multidisciplinary SciAdv r-articles Bioinorganic chemistry Human brain QP Copper Biometal R1 medicine.anatomical_structure Applied Sciences and Engineering chemistry visual_art visual_art.visual_art_medium Biophysics RC Research Article |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| Popis: | Discovery of nanometallic Cu0 with Fe0 in the human brain will fundamentally boost our understanding of neurobiology. The chemistry of copper and iron plays a critical role in normal brain function. A variety of enzymes and proteins containing positively charged Cu+, Cu2+, Fe2+, and Fe3+ control key processes, catalyzing oxidative metabolism and neurotransmitter and neuropeptide production. Here, we report the discovery of elemental (zero–oxidation state) metallic Cu0 accompanying ferromagnetic elemental Fe0 in the human brain. These nanoscale biometal deposits were identified within amyloid plaque cores isolated from Alzheimer’s disease subjects, using synchrotron x-ray spectromicroscopy. The surfaces of nanodeposits of metallic copper and iron are highly reactive, with distinctly different chemical and magnetic properties from their predominant oxide counterparts. The discovery of metals in their elemental form in the brain raises new questions regarding their generation and their role in neurochemistry, neurobiology, and the etiology of neurodegenerative disease. |
| Databáze: | OpenAIRE |
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