Black titanium dioxide@manganese dioxide for glutathione-responsive MR imaging and enhanced photothermal therapy
| Autor: | Zhibin Yin, Yang Gao, Sijia Sun, Aiguo Wu, Xiaolong Zhao, Leyong Zeng, Qian Ji, Zhengzheng Tao, Jiabing Jiang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Photothermal Therapy
Biomedical Engineering chemistry.chemical_element Nanoprobe Manganese Longitudinal Relaxation Rate chemistry.chemical_compound medicine Humans General Materials Science Titanium medicine.diagnostic_test Chemistry Magnetic resonance imaging Oxides General Chemistry General Medicine Glutathione Photothermal therapy Mr imaging Magnetic Resonance Imaging female genital diseases and pregnancy complications eye diseases Manganese Compounds Titanium dioxide Biomedical engineering |
| Zdroj: | Journal of materials chemistry. B. 9(2) |
| ISSN: | 2050-7518 |
| Popis: | Multifunctional nanoprobes with tumor microenvironment response are playing important roles in highly efficient theranostics of cancers. Herein, a kind of theranostic nanoprobe was synthesized by coating manganese dioxide (MnO2) on the surface of black commercial P25 titanium dioxide (b-P25). The resultant nanoprobe (b-P25@MnO2) possessed glutathione (GSH)-responsive magnetic resonance (MR) imaging and enhanced photothermal therapy (PTT). In tumor microenvironments, the excessive GSH was consumed by reacting with MnO2 to generate Mn2+ for GSH-responsive MR imaging, in which the longitudinal relaxation rate of b-P25@MnO2 was up to 30.44 mM-1 s-1, showing excellent cellular and intratumoral MR imaging. Moreover, the prepared b-P25@MnO2 exhibited stable and strong photothermal conversion capability with a high photothermal conversion efficiency of 30.67%, by which the 4T1 tumors disappeared completely, indicating safe and highly efficient PTT performance. The current work developed GSH-responsive b-P25@MnO2 nanoprobes, demonstrated for MR imaging and enhanced PTT in cancers. |
| Databáze: | OpenAIRE |
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