Downregulation of DHRS9 is associated with poor prognosis in oral squamous cell carcinoma
| Autor: | Chie Nakashima, Miyako Shimomura-Kurihara, Tadaaki Kirita, Hiroyuki Shimomura, Tomonori Sasahira |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Poor prognosis 3-Hydroxysteroid Dehydrogenases Down-Regulation Early detection Kaplan-Meier Estimate Reductase Disease-Free Survival Pathology and Forensic Medicine law.invention 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation law Biomarkers Tumor Humans Medicine Basal cell Aged Proportional Hazards Models Aged 80 and over Squamous Cell Carcinoma of Head and Neck business.industry Proportional hazards model Nodal metastasis Middle Aged Prognosis stomatognathic diseases 030104 developmental biology Head and Neck Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell Cancer research Suppressor Female Mouth Neoplasms business |
| Zdroj: | Pathology. 50:642-647 |
| ISSN: | 0031-3025 |
| DOI: | 10.1016/j.pathol.2018.06.002 |
| Popis: | Summary Oral squamous cell carcinoma (OSCC) has a high potential for local invasion and nodal metastasis. Therefore, early detection and elucidation of the detailed molecular mechanisms underlying OSCC are essential. Dehydrogenase/reductase member 9 (DHRS9) is downregulated in recurrent OSCC. Although DHRS9 is reported to act as a tumour suppressor in several malignancies, its expression in OSCC cells is unknown. In this study, we examined DHRS9 expression immunohistochemically in specimens from a sample of 98 OSCC patients. Reduced DHRS9 expression was observed in 68 of 98 patients (69.4%) with OSCC. A significant association was found between low DHRS9 expression and local progression (T factor) (p = 0.0135). Furthermore, patients with low DHRS9 expression had a significantly poorer prognosis than those with high DHRS9 expression (p = 0.0443). In multivariate analysis using the Cox proportional hazards model, decreased DHRS9 expression strongly correlated with worse prognosis. The study findings suggest that DHRS9 might be a useful diagnostic and prognostic marker for OSCC. |
| Databáze: | OpenAIRE |
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