Bioluminescent reporters to monitor killer cell–mediated delivery of granzymes inside target cells
| Autor: | Roel Broekhuizen, Stefanie A. H. de Poot, Jan Meeldijk, Elisabeth M. P. Steeghs, Elisabeth A. van Erp, Roel Goldschmeding, Niels Bovenschen, Marjolein C. Olthof |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
biology
Chemistry medicine.medical_treatment Immunology Leptocytes Apoptosis Biosensing Techniques Cell Biology Hematology Immunotherapy Biochemistry Granzymes Cell mediated immunity Cell biology Killer Cells Natural Granzyme Neoplasms medicine biology.protein Humans Bioluminescence Luciferase Immunobiology |
| Zdroj: | Blood. 126:2893-2895 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | To the editor: With great interest, we read the recent Blood article by Vrazo et al,[1][1] who report on the use of luciferase-based biosensors to detect proteolytic activity of granzymes (Gr’s) A, B, and K. They show that these sensors can be used to profile Gr delivery by natural killer (NK) |
| Databáze: | OpenAIRE |
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