Net Shape Nonwoven: a novel technique for porous three-dimensional nonwoven hybrid scaffolds
| Autor: | Ezzeding Laourine, Thomas Hanke, Martin Hild, Dilbar Aibibu, Maria Jäger, Ronny Brünler, Laura Scheid, Chokri Cherif, Danka Haupt |
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| Rok vydání: | 2014 |
| Předmět: |
Novel technique
Materials science Textile fiber based scaffold biomaterials chitosan tissue engineering Polymers and Plastics business.industry technology industry and agriculture Net shape Biocompatible material Bone tissue engineering Chitosan chemistry.chemical_compound Tissue engineering chemistry ddc:670 ddc:660 Faserbasiertes Gerüst Biomaterialien Chitosan Gewebetechnik Chemical Engineering (miscellaneous) Porosity business Biomedical engineering |
| Zdroj: | Textile Research Journal. 84:1084-1094 |
| ISSN: | 1746-7748 0040-5175 |
| DOI: | 10.1177/0040517513515315 |
| Popis: | Textile structures made of biocompatible, osteoconductive and resorbable chitosan-filaments provide excellent preconditions as scaffolds for Bone Tissue Engineering applications. The novel Net Shape Nonwoven (NSN) technique that enables short fibers to be processed into three-dimensional net-shaped nonwoven structures with adjustable pore size distributions is described. NSN scaffolds made of pure chitosan fibers were fabricated. NSN hybrid scaffolds for improved initial cell adhesion were realized by combining the NSN technique with electrospinning and dip-coating with collagen, respectively. Scanning electron microscopy and liquid displacement porosimetry revealed an interconnecting open porous scaffold structure. The novel chitosan-hybrid scaffolds provide proper conditions for adhesion, proliferation and differentiation of the seeded human bone marrow stromal cells, proving that they are suitable for usage in hard-tissue regeneration. |
| Databáze: | OpenAIRE |
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