Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750

Autor:	Daniel L. Flynn, Daniel P. Becker, Robert L. Shone, Gary W. Gullikson
Rok vydání:	2004
Předmět:	Agonist medicine.medical_specialty medicine.drug_class Vomiting medicine.medical_treatment Clinical Biochemistry Prokinetic agent Pharmaceutical Science Adamantane Pharmacology Biochemistry Serotonin 5-HT4 Receptor Agonists Dogs Gastrointestinal Agents In vivo Internal medicine Drug Discovery medicine Serotonin receptor activity Animals Serotonin 5-HT3 Receptor Antagonists Molecular Biology Aza Compounds Gastric emptying Chemistry Organic Chemistry Antagonist Rats Serotonin Receptor Agonists Endocrinology Benzamides Molecular Medicine Serotonin Cisplatin Gastrointestinal Motility
Zdroj:	Bioorganicmedicinal chemistry letters. 14(22)
ISSN:	0960-894X
Popis:	Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a-d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT(4) agonist and 5-HT(3) antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1eae133ccc8b139b6e673fc52afb58 https://pubmed.ncbi.nlm.nih.gov/15482914 Zobrazit plný text záznamu Full Text from ScienceDirect