Evaluation of the Anti-Diabetic Activity of Polysaccharide from Cordyceps cicadae in Experimental Diabetic Rats
| Autor: | O. O. Oluwaniyi, Adesola Julius Tola, Qianping Zhang, Hongxia Chen, Opeyemi Joshua Olatunji |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Administration Oral Bioengineering Biochemistry Antioxidants Diabetes Mellitus Experimental Glibenclamide Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Polysaccharides Alloxan Diabetes mellitus Internal medicine Glyburide medicine Animals Hypoglycemic Agents Molecular Biology Hypolipidemic Agents chemistry.chemical_classification biology Triglyceride Glutathione peroxidase General Chemistry General Medicine medicine.disease Rats 030104 developmental biology Endocrinology chemistry Alanine transaminase 030220 oncology & carcinogenesis Low-density lipoprotein Cordyceps Injections Intravenous biology.protein Molecular Medicine medicine.drug |
| Zdroj: | Chemistrybiodiversity. 15(8) |
| ISSN: | 1612-1880 |
| Popis: | Cordyceps cicadae is a medicinal fungus used in treating night sweat, childhood convulsions, vision improvement and pain. This study was designed to evaluate the anti-diabetic activity of the crude polysaccharide (SHF) from the mycelium and body portion of C. cicadae. Diabetes mellitus was induced in the rat with a single intravenous injection of alloxan monohydrate (150 mg/kg). In other to evaluate the anti-diabetic effects of C. cicadae polysaccharide in alloxan-induced diabetic rats, the crude polysaccharide (SHF at 100, 200 and 400 mg/kg body weight) and glibenclamide were administered orally to diabetic rats for 30 days. Blood glucose level, total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphate (ALP), creatinine (CREA), urea, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH) were determined. SHF showed significant reduction in blood glucose in diabetic rats. Treatment of diabetic rats also resulted an improvement in body weights, increased HDL, SOD and GSH, as well as decreased TC, TG, LDL, MDA, urea, CREA, ALT, AST and ALP. These results suggested that C. cicadae polysaccharide displayed anti-hyperglycemic, anti-hyperlipidemic and antioxidant activities and could be a promising therapeutic source in managing diabetes mellitus and its associated complications. |
| Databáze: | OpenAIRE |
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