Suppression of arterial pressure, heart rate and cardiac contractility following microinjection of kainic acid into the nucleus ambiguus of the rat
| Autor: | B.T. Ong, Peter T.-H. Wong, Samuel H.H. Chan |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Chronotropic
Inotrope Bradycardia Male medicine.medical_specialty Pyrrolidines Microinjections Blood Pressure Contractility Heart Rate Internal medicine Heart rate medicine Animals Microinjection Nucleus ambiguus Medulla Oblongata Kainic Acid business.industry General Neuroscience Rats Inbred Strains Myocardial Contraction Rats Blood pressure Anesthesia Cardiology medicine.symptom business |
| Zdroj: | Neuroscience letters. 47(1) |
| ISSN: | 0304-3940 |
| Popis: | In pentobarbital anesthetized rats, unilateral microinjection (500 ng) of the selective perikaryal excitotoxin, kainic acid, into the nucleus ambiguus promoted a significant suppression of arterial pressure, heart rate and cardiac contractility. The degree of such cardiovascular depression followed the order of heart contractility reduction (50.7%) greater than hypotension (28.9%) greater than bradycardia (20.8%) at the end of a 60-min postinjection period. We concluded that the nucleus ambiguus may exert its control on cardiac activities by both negative chronotropic and inotropic effects on the heart. |
| Databáze: | OpenAIRE |
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