Methotrexate Induced Pancytopenia
| Autor: | Hazem Alsaadi, Amer Syed, Sahar Eivaz-Mohammadi, Fernando Gonzalez-Ibarra, Valentin Marian, Shiri Surapaneni, Simon Badin, Mazhar Elamir |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Drug
musculoskeletal diseases medicine.medical_specialty lcsh:Diseases of the musculoskeletal system business.industry media_common.quotation_subject Case Report General Medicine Pharmacology medicine.disease Pancytopenia Gastroenterology immune system diseases Internal medicine Rheumatoid arthritis Transfusion dependence medicine Mucositis Methotrexate Dosing lcsh:RC925-935 business Severe neutropenia media_common medicine.drug |
| Zdroj: | Case Reports in Rheumatology, Vol 2014 (2014) Case Reports in Rheumatology |
| ISSN: | 2090-6897 2090-6889 |
| Popis: | The well-reported methotrexate (MTX) toxicities are based on the duration and cumulative dosing of drug. The typical toxicities can be predicted by the timing of drug administration, where mucositis occurs as an earlier effect, while myelosuppression and the sequelae of pancytopenia occur later after MTX administration. Despite these well-known toxicities, low dose MTX therapy can become problematic, in particular with the elderly, who are at a greater risk for significant myelosuppression. We present a case of a 73-year-old female with pancytopenia causing severe neutropenia, mucocutaneous bleeding, and bruising and requiring intravenous antibiotic therapy and limited transfusion dependence as a result of low dose daily MTX for rheumatoid arthritis. |
| Databáze: | OpenAIRE |
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