Canine Cutaneous Clear Cell Adnexal Carcinoma: Histopathology, Immunohistochemistry, and Biologic Behavior of 26 Cases
| Autor: | F. Y. Schulman, T. P. Lipscomb, T. J. Atkin |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Pathology Skin Neoplasms 040301 veterinary sciences Biology Hidradenocarcinoma 0403 veterinary science 03 medical and health sciences Cytokeratin Dogs Carcinoma medicine Animals Dog Diseases Lymph node General Veterinary Carcinoma Skin Appendage 04 agricultural and veterinary sciences medicine.disease 030104 developmental biology medicine.anatomical_structure Female Histopathology Epithelioid cell Clear cell Adnexal Carcinoma Adenocarcinoma Clear Cell |
| Zdroj: | Journal of Veterinary Diagnostic Investigation. 17:403-411 |
| ISSN: | 1943-4936 1040-6387 |
| Popis: | Thirty tumors including 27 distinctive cutaneous neoplasms and 3 metastatic tumors from 26 dogs were collected from diagnostic submissions to 3 laboratories. Characteristic histopathologic features included location in the subcutis or dermis (or both); lobular, nodular, and nest-like architecture; and a component of epithelioid cells with clear cytoplasm. Additional features present in most cases included follicular dermal papilla-like structures, low mitotic index, nuclear pleomorphism, necrosis, and mineralization. Cytoplasmic periodic acid Schiff—positivity, which was abolished by pretreatment with diastase, indicated the presence of glycogen in all cases. The oil red O stain did not demonstrate cytoplasmic lipid. Melanin granules, accentuated by the Fontana-Masson method, were observed infrequently. A sparsely cellular mucinous stroma and stromal cartilaginous differentiation were uncommon. By immunohistochemistry, neoplastic cells stained positively for cytokeratin (29 of 29), vimentin (28 of 28), S-100 protein (24 of 29), and melan A (8 of 12); results were negative for smooth muscle actin and calponin in all cases. Clinical follow-up information was obtained on all 26 dogs. One tumor recurred, 1 metastasized to a regional lymph node, and 1 metastasized to regional lymph nodes twice. In another case, possible pulmonary metastasis was noted radiographically. The findings are consistent with a poorly differentiated, low-grade, adnexal carcinoma of the skin. Similar canine cutaneous neoplasms have been reported as “clear-cell hidradenocarcinoma” and “follicular stem cell carcinoma.” The authors propose the designation “cutaneous clear cell adnexal carcinoma.” |
| Databáze: | OpenAIRE |
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