Relative tumour promoting activity of three polychlorinated biphenyls in rat liver
| Autor: | Ingrid Nordgren, Tony Kronevi, Ulf G. Ahlborg, Åke Bergman, Helena Hemming, Sten Flodström, Lars Wärngård |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Polychlorinated Dibenzodioxins Microgram Polychlorinated dibenzodioxins Tumor initiation Toxicology Rats Sprague-Dawley chemistry.chemical_compound Structure-Activity Relationship Liver Neoplasms Experimental Liver tissue Internal medicine medicine Animals Gamma-glutamyltransferase Carcinogen Glutathione Transferase Pharmacology biology gamma-Glutamyltransferase Pollution Polychlorinated Biphenyls Rats Endocrinology chemistry Liver Rat liver biology.protein Carcinogens Tumor promotion Female |
| Zdroj: | European journal of pharmacology. 248(2) |
| ISSN: | 0014-2999 |
| Popis: | The relative tumour promoting activity of three structurally and toxicologically diverse polychlorinated biphenyls (3,4,5,3',4'-penta- 2,3,4,3',4'-penta- and 2,4,5,2',4',5'-hexachlorobiphenyl) was measured in an initiation/promotion assay in nitrosodiethylamine-initiated female Sprague-Dawley rats. The congeners under study were administered by once-weekly subcutaneous injections for 20 weeks. Evaluation of the development of gamma-glutamyl transpeptidase (GGT)- and glutation transferase P (GST-P)-positive hepatic foci showed that all congeners promoted altered hepatic foci, although 3,4,5,3',4'-pentachlorobiphenyl was far more potent. The volume fraction of the liver occupied by GGT-positive tissue in the 3,4,5,3',4'-pentachlorobiphenyl-treated animals (100 micrograms/kg per week) was 23%, while the volume fractions of altered liver tissue in the rats treated with 2,3,4,3',4'-pentachlorobiphenyl (5000 micrograms/kg per week) and 2,4,5,2',4',5'-hexaCB (20,000 micrograms/kg per week) were 1.2 and 2.3, respectively. The enhancement of GGT- and GST-P-positive foci was accompanied by an increased incidence of histological changes in the livers. |
| Databáze: | OpenAIRE |
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