Plasminogen Activator Inhibitor 1 4G/5G and −844G/A Variants in Idiopathic Recurrent Pregnancy Loss
| Autor: | Wassim Y. Almawi, Viviana G. Herbepin, Touhami Mahjoub, Renaud Touraine, Kalthoum Magdoud |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Abortion Habitual Genotype medicine.medical_treatment Immunology Biology Bioinformatics Polymerase Chain Reaction Polymorphism Single Nucleotide Andrology chemistry.chemical_compound Gene Frequency Pregnancy Risk Factors Polymorphism (computer science) Plasminogen Activator Inhibitor 1 Recurrent miscarriage Genetic model Fibrinolysis medicine Humans Immunology and Allergy Genetic Predisposition to Disease Promoter Regions Genetic Genotyping DNA Primers Polymorphism Genetic Haplotype Obstetrics and Gynecology medicine.disease Minor allele frequency Reproductive Medicine chemistry Case-Control Studies Plasminogen activator inhibitor-1 Female |
| Zdroj: | American Journal of Reproductive Immunology. 70:246-252 |
| ISSN: | 1046-7408 |
| DOI: | 10.1111/aji.12116 |
| Popis: | Problem Plasminogen activator inhibitor type 1 (PAI-1) regulates fibrinolysis, and the common promoter region variants −675G/A (4G/5G) and −844G/A are associated with increased thrombotic risk. Despite evidence linking altered fibrinolysis with adverse pregnancy events, including idiopathic recurrent pregnancy loss (RPL), the contribution of PAI-1 variants to RPL risk remains controversial. We investigated the association between the PAI-1 −844G/A and 4G/5G (−675G/A) variants with altered risk of RPL. Method of study This was a case–control study involving 304 women with confirmed RPL and 371 age- and ethnically matched control women. PAI-1 genotyping was performed by PCR single-specific primer −675 (G/A) and real-time PCR (−844G/A) analysis. Results Minor allele frequency (MAF) of 4G/5G (P |
| Databáze: | OpenAIRE |
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