The Value of the Bone Marrow Plasma Cell Cytoplasmic Light Chain Ratio in Differentiating Between Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance
| Autor: | N. G. P. Slater, R. J. Grace, Ankita Singh, Gauranga Majumdar |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Cytoplasm Cancer Research Pathology medicine.medical_specialty Plasma Cells Paraproteinemias Plasma cell Immunoglobulin light chain Diagnosis Differential Bone Marrow immune system diseases hemic and lymphatic diseases Humans Medicine cardiovascular diseases Multiple myeloma Aged business.industry Hematology Middle Aged medicine.disease Isotype medicine.anatomical_structure Oncology Paraprotein level Female Immunoglobulin Light Chains Bone marrow Multiple Myeloma business Monoclonal gammopathy of undetermined significance Paraproteins |
| Zdroj: | Leukemia & Lymphoma. 8:491-493 |
| ISSN: | 1029-2403 1042-8194 |
| Popis: | We compared the plasma cell light chain ratios in the bone marrows of 13 patients with multiple myeloma (MM), with those of 13 patients with monoclonal gammopathy of undetermined significance (MGUS). The mean light chain ratio in favour of the paraprotein isotype in the myeloma group was 51.83 (95% confidence limits (CL) 29.52-74.14), while in the MGUS group it was 5.30 (CL 2.07-8.52). The difference between the MGUS and MM groups was significant (p = 0.0005). Neither the bone marrow plasma cell count nor the paraprotein level were significantly correlated with the light chain ratio in either of these two groups. We found a cut-off ratio of 8 to be the most useful in differentiating between myeloma and MGUS. Only one patient with myeloma had a ratio below 8, and one MGUS patient had a ratio above this cut-off point. We conclude that determination of the bone marrow plasma cell light chain ratio is a simple and useful test in differentiating between myeloma and MGUS in difficult cases. |
| Databáze: | OpenAIRE |
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