Aspergillus nidulans contains six possible fatty acyl-CoA synthetases with FaaB being the major synthetase for fatty acid degradation
| Autor: | Michael J. Hynes, Kathrin Reiser, Meryl A. Davis |
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| Rok vydání: | 2010 |
| Předmět: |
Long-chain-fatty-acid—CoA ligase
Fatty acid degradation Biochemistry Microbiology Aspergillus nidulans Fungal Proteins chemistry.chemical_compound Coenzyme A Ligases Genetics Molecular Biology Beta oxidation biology Genomics General Medicine Metabolism Peroxisome biology.organism_classification Fatty acid synthase chemistry biology.protein Free fatty acid receptor Acyl Coenzyme A Genome Fungal Gene Deletion |
| Zdroj: | Archives of Microbiology. 192:373-382 |
| ISSN: | 1432-072X 0302-8933 |
| DOI: | 10.1007/s00203-010-0565-9 |
| Popis: | Aspergillus nidulans can use a variety of fatty acids as sole carbon and energy sources via its peroxisomal and mitochondrial beta-oxidation pathways. Prior to channelling the fatty acids into beta-oxidation, they need to be activated to their acyl-CoA derivates. Analysis of the genome sequence identified a number of possible fatty acyl-CoA synthetases (FatA, FatB, FatC, FatD, FaaA and FaaB). FaaB was found to be the major long-chain synthetase for fatty acid degradation. FaaB was shown to localise to the peroxisomes, and the corresponding gene was induced in the presence of short and long chain fatty acids. Deletion of the faaB gene leads to a reduced/abolished growth on a variety of fatty acids. However, at least one additional fatty acyl-CoA synthetase with a preference for short chain fatty acids and a potential mitochondrial candidate (AN4659.3) has been identified via genome analysis. |
| Databáze: | OpenAIRE |
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