Thyroid dysfunction after combined therapy for laryngeal cancer: a prospective study
| Autor: | Memet Çiftçic, Esra Sözen, Serdar Baylancicek, Seyhan Alkan, Burhan Dadaş |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Thyroid Lobectomy Laryngectomy Thyroid Function Tests Thyroid function tests Thyroiditis Risk Factors medicine Humans Prospective Studies Risk factor Prospective cohort study Laryngeal Neoplasms Neoplasm Staging Chi-Square Distribution medicine.diagnostic_test business.industry Incidence Neck dissection Radiotherapy Dosage Middle Aged medicine.disease Combined Modality Therapy Thyroid Diseases Surgery Logistic Models Otorhinolaryngology Neck Dissection Thyroid function business |
| Zdroj: | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 139(6) |
| ISSN: | 0194-5998 |
| Popis: | Objective The purpose of this study was to assess the incidence of the thyroid dysfunction in a group of patients treated with laryngectomy and radiotherapy for larynx cancer and to analyze the risk factors related to the development of hypothyroidism. Study Design This was a prospective study conducted in a tertiary center hospital. Subjects and Methods Thyroid function tests have been applied to 75 patients treated with surgery and radiotherapy preoperatively, before radiotherapy, and postoperatively. Risk factors have been analyzed by carrying out a multivariate analysis. Results All the patients were men with the mean age of 59.4 and an average follow-up of 28.6 months. The incidence of hypothyroidism was 49.3 percent. The average time to detection of hypothyroidism was 6 months after the completion of treatment. Radiotherapy dose, type of laryngectomy, extent of neck dissection, implementation of thyroid lobectomy, and presence of thyroiditis in specimens were risk factors for thyroid dysfunction. Conclusions It is important to check the thyroid function periodically in these patients especially with risk factor to obtain early diagnosis and appropriate treatment. |
| Databáze: | OpenAIRE |
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