High soluble HLA-DQB2 levels in posttransplant serum are associated with kidney graft dysfunction

Autor:	Karina L Mine, Renato Marco, Tamiris R.F. Raimundo, Julia V. Ernesto, José O. Medina‐Pestana, Hélio Tedesco‐Silva, Maria Gerbase‐DeLima
Rok vydání:	2021
Předmět:	Cohort Studies Graft Rejection Immunology Graft Survival Genetics Humans General Medicine Kidney Molecular Biology Kidney Transplantation Genetics (clinical) Tissue Donors
Zdroj:	International journal of immunogeneticsREFERENCES. 49(2)
ISSN:	1744-313X
Popis:	HLA-DQB2 is a gene of limited polymorphism, with unknown function that presents at least two transcript variants: v1, which encodes the full-length beta-chain, and v2, which lacks exon 4 and could give rise to a soluble protein. We previously showed a strong correlation between high v2 expression in preimplantation biopsies (PIB) of kidneys from young (18- to 49-year olds) but not from old, deceased donors and 1-year posttransplant low (estimated glomerular filtration rate 45 ml/min/1.73 m
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0632a38808a1a9eddc8e01deb28bcb https://pubmed.ncbi.nlm.nih.gov/35083872 Zobrazit plný text záznamu Plný text