Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma—an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial
| Autor: | Beate Timmermann, Christiane Matuschek, Annett Braesigk, Silke Frick, Stefan Rutkowski, Ralf Kitzing, Stefan Dietzsch, Kristin Gurtner, Julia Remmele, Denise Obrecht, Nicolas U. Gerber, Rolf-Dieter Kortmann, Karin Dieckmann, Tina Schlender, Montserrat Pazos, Martin Benesch, V. Lewitzki, Damien C. Weber, Clemens Seidel, Karolina Jablonska, Dirk Geismar, Martin Mynarek, Semi Harrabi, Albrecht Glück, Rudolf Schwarz |
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| Přispěvatelé: | University of Zurich, Dietzsch, Stefan |
| Rok vydání: | 2021 |
| Předmět: |
Quality Control
medicine.medical_specialty medicine.medical_treatment Medizin Planning target volume 610 Medicine & health Protocol Deviation Germany 2741 Radiology Nuclear Medicine and Imaging Humans Medicine Radiology Nuclear Medicine and imaging Tumor bed Medical physics Cerebellar Neoplasms Protocol (science) Medulloblastoma business.industry Radiotherapy Planning Computer-Assisted medicine.disease Radiation therapy Clinical trial Oncology 10036 Medical Clinic Radiation Oncology 2730 Oncology business Quality assurance |
| Zdroj: | Dietzsch, Stefan; Braesigk, Annett; Seidel, Clemens; Remmele, Julia; Kitzing, Ralf; Schlender, Tina; Mynarek, Martin; Geismar, Dirk; Jablonska, Karolina; Schwarz, Rudolf; Pazos, Montserrat; Weber, Damien C; Frick, Silke; Gurtner, Kristin; Matuschek, Christiane; Harrabi, Semi Ben; Glück, Albrecht; Lewitzki, Victor; Dieckmann, Karin; Benesch, Martin; ... (2022). Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma-an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial. Strahlentherapie und Onkologie, 198(3), pp. 282-290. Springer 10.1007/s00066-021-01822-0 |
| ISSN: | 1439-099X 0179-7158 |
| DOI: | 10.1007/s00066-021-01822-0 |
| Popis: | Purpose In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but was recommended for patients enrolled in the SIOP PNET5 MB trial between 2014 and 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations in the initial plan proposals and develop uniform review criteria for TB boost. Patients and methods A total of 78 patients were registered in this trial, of whom a subgroup of 65 patients were available for evaluation of the TB treatment plans. Dose uniformity was evaluated according to the definitions of the protocol. Additional RT-QC criteria for standardized review of target contours were elaborated and data evaluated accordingly. Results Of 65 initial TB plan proposals, 27 (41.5%) revealed deviations of target volume delineation. Deviations according to the dose uniformity criteria were present in 14 (21.5%) TB plans. In 25 (38.5%) cases a modification of the RT plan was recommended. Rejection of the TB plans was rather related to unacceptable target volume delineation than to insufficient dose uniformity. Conclusion In this analysis of pretreatment RT-QC, protocol deviations were present in a high proportion of initial TB plan proposals. These findings emphasize the importance of pretreatment RT-QC in clinical trials for MB. Based on these data, a proposal for RT-QC criteria for tumor bed boost in non-metastatic MB was developed. |
| Databáze: | OpenAIRE |
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