Effect of polybrominated biphenyls, β-naphthoflavone and phenobarbital on arylhydrocarbon hydroxylase activities and chloroform-induced nephrotoxicity and hepatotoxicity in male C57BL/6J and DBA/2J mice
| Autor: | Jerry B. Hook, Chao-Hen Kuo, Massumeh Ahmadizadeh, Robert Echt |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Polybrominated Biphenyls beta-Naphthoflavone Kidney Toxicology Blood Urea Nitrogen Nephrotoxicity Mice chemistry.chemical_compound Species Specificity Internal medicine medicine Animals Blood urea nitrogen Benzoflavones Flavonoids Chloroform Dose-Response Relationship Drug integumentary system Alanine Transaminase Mice Inbred C57BL Dose–response relationship medicine.anatomical_structure Endocrinology Liver chemistry Mice Inbred DBA Enzyme Induction Phenobarbital Aryl Hydrocarbon Hydroxylases medicine.drug |
| Zdroj: | Toxicology. 31:343-352 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/0300-483x(84)90116-1 |
| Popis: | Administration of chloroform (CHCl3) to male C57/6J (C57) and DBA/2J (DBA) mice produced dose-dependent hepatic and renal damage. Hepatic arylhydrocarbon hydroxylase (AHH) activity was higher in C57 than DBA mice; in kidney, AHH activity was higher in DBA than in C57 mice. CHCl3 caused the same degree of liver damage in both strains of mice; however, nephrotoxicity of CHCl3 was greater in DBA than in C57 mice. Pretreatment of C57 and DBA mice with phenobarbital (PB) markedly increased hepatic AHH activity and hepatotoxicity of CHCl3 in both strains but did not affect renal AHH or nephrotoxicity of CHCl3. Similarly, beta-naphthoflavone (BNF) enhanced AHH activity and CHCl3 hepatotoxicity in C57 mice, but had little effect on nephrotoxicity. BNF did not affect hepatic AHH nor CHCl3-induced hepatic injury in male DBA mice. Pretreatment with polybrominated biphenyl (PBB) enhanced AHH activity in liver and CHCl3 hepatotoxicity in both strains. After PBB, nephrotoxicity of CHCl3 and renal AHH activity were increased in C57 mice whereas PBB did not alter nephrotoxicity or renal AHH in DBA mice. These results suggest that CHCl3-nephrotoxicity is independent of hepatotoxicity. |
| Databáze: | OpenAIRE |
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