Neural tissue engineering: the influence of scaffold surface topography and extracellular matrix microenvironment
| Autor: | Nai-Wen Liang, Wei-Yuan Huang, Liang-Hsin Chen, Tzu-Wei Wang, Huan-Chih Wang, Chun-Yi Yang, Jiaju Lu, Xiumei Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Scaffold
Neurite Surface Properties Biomedical Engineering Biocompatible Materials 02 engineering and technology Neural tissue engineering Extracellular matrix 03 medical and health sciences Cell Adhesion Animals Humans General Materials Science Particle Size Neural cell Cell Proliferation 030304 developmental biology Neurons 0303 health sciences Tissue Engineering Chemistry Axon extension General Chemistry General Medicine 021001 nanoscience & nanotechnology Neural stem cell Extracellular Matrix Cell biology Neural tissue regeneration 0210 nano-technology |
| Zdroj: | Journal of Materials Chemistry B. 9:567-584 |
| ISSN: | 2050-7518 2050-750X |
| DOI: | 10.1039/d0tb01605e |
| Popis: | During nervous system development, an extracellular matrix (ECM) plays a pivotal role through surface topography and microenvironment signals in neurons and neurites maturation. Topography and microenvironment signals act as physical and chemical guiding cues, respectively, for neural tissue formation and reconstruction. Imposed surface topography can affect neural stem cells by promoting adhesion, spreading, alignment, morphological changes, and specific gene expression. Therefore, fabrication of a biomimetic construct or scaffold to support neurite outgrowth and axon extension is a crucial and common strategy for neural tissue regeneration. Here, we review recent developments in biomaterials modification for simulating the microenvironment to promote neural cell adhesion and growth. The subtopics include those of potential cellular mechanisms of topographical response, topography on cellular organization and function, contact guidance in neurite outgrowth and axon growth, ECM microenvironment as regulatory cues, as well as challenges and future perspectives of nerve conduits that are now in clinical trials and usage. |
| Databáze: | OpenAIRE |
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